La interrupcion de las interacciones de factor de crecimiento / receptor y de la cascada de senales de traduccion y factores de transcripcion resultaria en una
vasculogenesis anormal y en consecuencia a defectos vasculares tales como displasias, origen o curso aberrante, agenesia, hipoplasia, estenosis, oclusion, persistencia de vasos fetales, y por ende un deficit de flujo sanguineo a campos de desarrollo primario y secundario (organogenesis).
Specifically, ranibizumab is an anti-VEGF A antibody which inhibits
vasculogenesis and causes regression of existing vessels.
Arsenic exposure in pregnant mice disrupts placental
vasculogenesis and causes spontaneous abortion.
Although some observations identify a direct suppression of
vasculogenesis by BPs, it can be difficult in bone to distinguish between inhibition of new vessel growth and suppression of osteoclastic activity because both are coupled.
49) La etiologia de la hipoplasia del tercio medio facial en estos ratones, fue una consecuencia de una proliferacion celular reducida de las CCNC en el tercio medio facial, aberrante
vasculogenesis y deficiente produccion de matriz extracelular en los procesos palatinos, asociados con un crecimiento anormal de la region facial.
First they set out the basic CPM and its applications, then describe extended versions such as a wound healing assay, the effect of calcium-related pathways on single cell motility, tumor-derived
vasculogenesis, and cancer cell migration in matrix microchannels.
Reduced gravity also altered angeogenesis and
vasculogenesis and promoted genes involved in rheumatoid arthritis, tumor growth and wound repair.
The key role of this receptor in developmental angiogenesis and hematopoiesis is evidenced by lack of
vasculogenesis and failure to develop blood islands and organized blood vessels in Flk-1 null mice, resulting in death in utero.
There are different theories of its manifestation especially on abnormal
vasculogenesis during embryonic and foetal development.
Identification of a novel role of T-cells in postnatal
vasculogenesis," Circulation, Vol.
AIF-I expression regulates endothelial cell activation, signal transduction, and
vasculogenesis.
Puca said the goal was modulating intracellular trafficking of tyrosine kinase receptors, cellular proteins directly involved in
vasculogenesis, in the context of cell and tissue morphogenesis, ultimately emphasizing the properties of mechanical loading via simulated microgravity and its effects on hematopoietic stem cell (HSPC) growth.
