The arterial system model introduces throughout the body's network of arteries a pulsating blood simulant that can mimic clotting if needed, allowing researchers and trainees to experience lifelike vascular reactions
to surgical procedures and devices.
In 1913 Eppinger (37) was the first to show the involvement of histamine in vascular reactions
of the skin and in 1917 Sollmann and Pilcher (38) reported that morphine caused the triple response in human skin; that is, an initial red spot followed by a red irregular flare and then a fluid-filled wheal.
All groups of PDT-treated animals with single and fractionated hypericin dosing presented primary vascular reactions including vascular dilatation, congestion, thrombosis and oedema.
Microscopically the penetrating growth of MFS towards the subcutaneous muscular tissue led to partial muscular destruction and local inflammatory and vascular reactions.
In our experiments, all groups of PDT-treated animals with single and fractionated hypericin dosing presented primary vascular reactions.
Our histomorphological observation after hypericin-based PDT of G5:1:13 murine fibrosarcoma showed that in all therapeutical groups of animals with single and fractionated hypericin dosing, the consequence was represented by primary vascular reactions which progressed to continuous tumour tissue necrosis.
I had the witness reestablish that he knew of no cocaine- and alcohol-induced vascular reactions that damaged the spine.
These findings could not have been caused by a cocaine- and alcohol-induced vascular reaction.
To date, clinical trials of Dyloject have shown fewer vascular reactions
at the injection site than Voltarol, and an absence of cardiovascular adverse events.