vascular disrupting agent


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vascular disrupting agent

Any of a class of medications used to destroy the blood supply of malignant tumors.
See also: agent
References in periodicals archive ?
The company's major focus is developing vascular disrupting agents (VDAs) that selectively disrupt abnormal blood vessels associated with solid tumor progression.
The studies were conducted in mouse xenograft and orthotopic models of AML and showed that OXi4503, a second-generation, dual-action vascular disrupting agent (VDA), demonstrated a higher level of anti-leukemic activity when administered as a single agent or in combination with bevacizumab, an anti-VEGF antibody, than when bevacizumab was used alone.
Building upon early stage microbial discoveries by researchers at the University of California, San Diego's Scripps Institution of Oceanography, Nereus is developing a novel and highly selective tumour vascular disrupting agent (VDA; NPI-2358) derived from a marine fungus and a potent second generation proteasome inhibitor (NPI-0052) isolated from a novel marine bacteria.

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