They faithfully ease the tumour cells to breach cellular boundaries by successively limiting tumour cells to vascular compartment
, escaping immunological checkpoints and potentiating invasiveness and eventually colonizing distant tissues.
Changes of the vasculature and downstream effects on HSC and other niche cells will be analyzed during therapeutic targeting of leukemia and the vascular compartment
will be evaluated as novel target for niche-targeting leukemia combination therapies.
The researchers' next steps are to identify the appropriate cells to regenerate the vascular compartment
of the kidney as well as the compartment of the kidney responsible for blood filtration.
The pathophysiology of OHSS is characterised by increased capillary permeability, leading to leakage of fluid from the vascular compartment
to the extra vascular space with third space fluid accumulation and intravascular volume depletion.
According to Stems (2013), two primary steps occur in edema formation: (a) movement of the fluid from the vascular compartment
to the interstitial compartment as a result of altered dynamics, and (b) retention of sodium and water by the kidneys.
These pressures may result in large fluid shifts from the vascular compartment
into the interstitium and subsequently into the alveoli as the rate of removal of fluid by the lymphatic system is greatly exceeded (6,7).
6%) subjects presented with hemorrhage in more than one vascular compartment
They therefore remain in the vascular compartment
with a long intravascular half-life, (2,7) which is helpful in localising the site of enteric protein loss.
5 h) hypericin was located in the vascular compartment
of the tumour, but 6 and 24 h later it was located in the interstitial and cellular compartments (Chen et al.
In some patients, the fluid shift from the vascular compartment
leads to shock and death (6,7,9).
Serum lipoproteins escape from the vascular compartment
and enter connective tissue at sites of increased vascular permeability.
In the study, co-authored by scientists from the Joslin Diabetes Center, an affiliate of Harvard Medical School, and ActiveSite Pharmaceuticals, the integrity of the blood-retinal barrier in diabetic rats was measured using a well-established technique that measures the leakage of the plasma protein albumin from the vascular compartment
into the retina.