variola


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variola

 [vah-ri´o-lah]
smallpox. adj., adj vari´olar, vario´lous.
variola mi´nor a mild form of smallpox having a low fatality rate.

small·pox

(smawl'poks),
An acute eruptive contagious disease caused by a poxvirus (Orthopoxvirus, a member of the family Poxviridae) and marked at the onset by chills, high fever, backache, and headache. In 2-5 days these constitutional symptoms subside and an eruption appears as papules, which become umbilicated vesicles, develop into pustules, dry, and form scabs that, on falling off, leave a permanent marking of the skin (pock marks). The average incubation period is 8-14 days. As a result of increasingly aggressive vaccination programs carried out over a period of about 200 years, smallpox is now extinct.
Synonym(s): variola major, variola
[E. small pocks, or pustules]

Smallpox was a universally dreaded scourge for more than 3 millennia, with case fatality rates sometimes exceeding 20%. In many ways a unique disease, it had no nonhuman reservoir species and no asymptomatic human carriers. First subjected to some control by variolation in the 10th century in India and China, it was gradually suppressed in the industrialized world after Edward Jenners 1776 landmark demonstration that infection with the harmless cowpox (vaccinia) virus renders humans immune to the smallpox virus. The last case diagnosed in the U.S. occurred in 1949. A global eradication program was initiated by the World Health Organization in 1966, and the last naturally occurring case of the disease was reported in Somalia in 1977. Routine vaccination against smallpox, discontinued in the 1970s, has been resumed for military and health care personnel and others who would be at high risk if smallpox virus should be used as a weapon of biologic warfare or bioterrorism.

variola

(və-rī′ə-lə, vâr′ē-ō′lə, văr′-)
n.

va·ri·o·la

(var-ī'ō-lă)
1. Species type of the genus Orthopoxvirus that causes human smallpox.
2. Smallpox.
[Med. L. dim of L. varius, spotted]

variola

An alternative term for SMALLPOX.

va·ri·o·la

(vă-rī'ō-lă)
1. Species type of the genus Orthopoxvirus that causes human smallpox.
2. Smallpox.
[Med. L. dim of L. varius, spotted]
References in periodicals archive ?
PROF GEOFFREY SMITH: "Of course, when one thinks of variola virus, the cause of smallpox, such activity is absolutely prohibited.
(9) No curso Seguranca, Territorio, Populacao, Foucault explica o modo de funcionamento das "curvas de normalidade" ao analisar as praticas de variolizacao: "Vai-se ter a destruicao 'normal' dos casos de afeccao por variola em cada idade, em cada regiao, em cada cidade, nos diferentes bairros da cidade, conforme as diferentes profissoes das pessoas.
Em torno de 6 da tarde do dia 10 de novembro, alguns jovens estudantes, no Largo de Sao Francisco, desceram a rua do Ouvidor e um deles, Jayme Cohen, comecou a protestar resistencia a vacina contra variola. Quando um delegado de policia intimou Jayme para ir a delegacia, ocorreu uma reacao das pessoas presentes em face da acao policial.
Eradication was made possible by the ability of vaccinia virus to induce cross-protective immunity against other viruses within the orthopoxvirus genus capable of producing human infection (e.g., variola, monkeypox, and cowpox) (3).
El virus Variola se transmite por las secreciones orales, nasales y faringeas de las personas enfermas, al ser estas inhaladas por individuos con sistemas inmunologicos aptos para el desarrollo del virus.
Igualmente, por asumir que era una variante fea de la sarna, algunos medicos la nombraban a veces como scabies grossa, scabies mala, scabies epidermica, rogna grossa o glutinosa scabies-, no obstante, eran mas comunes las expresiones asociadas con la viruela, o sea grosse verole, grosse vayrolle, variola grossa, variola croniqua, specie variolarum, variola gailica, vaiolo spagnolo y great pox (9).
A partir da leitura de contos de autores como Monteiro Lobato, Joao do Rio e Coelho Neto, o pesquisador demonstra como a sifilis, a febre amarela, a variola, a peste bubonica e a hanseniase exerceram significativa influencia em narrativas cujas estruturas e tematicas guardam semelhancas com a literatura gotica europeia e norte-americana.
Although closely related to the variola virus that causes smallpox, it is generally harmless to humans.
During decades, VACV was used as the vaccine strain in the world programme of eradication of smallpox, due to its low virulence and antigenic similarity with the agent of smallpox, variola virus (VarV) (BAXBY, 1977).