vanillylmandelic acid


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vanillylmandelic acid

 [vah-nil″il-man-del´-ik]
VMA; the primary end-product of catecholamine metabolism excreted in the urine. Urinary VMA levels are used in screening patients for pheochromocytoma.

va·nil·lyl·man·del·ic ac·id (VMA),

(vă-nil'il-man-del'ik as'id),
Misnomer for 4-hydroxy-3-methoxymandelic acid (α,3-dihydroxy-2-methoxybenzeneacetic acid); the major urinary metabolite of adrenal and sympathetic catecholamines (for example, from both epinephrine and norepinephrine); elevated in most patients with pheochromocytoma.

vanillylmandelic acid

/va·nil·lyl·man·del·ic ac·id/ (vah-nil″il-man-del´ik) an excretory product of the catecholamines; urinary levels are used in screening patients for pheochromocytoma. Abbreviated VMA.

vanillylmandelic acid (VMA)

[vənil′ilməndel′ik]
a urinary metabolite of epinephrine and norepinephrine. It may be measured in the urine to determine the levels of these catecholamines. A greater than normal amount of VMA is characteristic of a pheochromocytoma or neuroblastoma. Increased concentrations of this acid may raise the blood pressure and indicate the presence of tumors of the adrenal glands or nervous system, muscular dystrophy, and myasthenia gravis; they may be caused by stress, exercise, or certain drugs or foods. Normal amounts in the urine of adults after 24-hour collection are 1.5 to 7.5 mg; in the urine of infants, it is 83 mg/kg of body weight. Also called 3-methoxy-4-hydroxymandelic acid.

va·nil·lyl·man·del·ic ac·id

(VMA) (vă-nil'il-man-del'ik as'id)
The major urinary metabolite of adrenal and sympathetic catecholamines; elevated in most patients with pheochromocytoma.

vanillylmandelic acid

an excretory product of the catecholamines found in the urine; used as a test in the diagnosis of phaeochromocytoma.
References in periodicals archive ?
4], tetrahydrobiopterin; THD, tyrosine hydroxylase deficiency; CSF, cerebrospinal fluid; 5-HIAA, 5-hydroxyindoleacetic acid; HVA, homovanillic acid; MHPG, 3-methoxy-4-hydroxy-phenylglycol; and VMA, vanillylmandelic acid.
An immunoassay that uses monoclonal antibodies against HVA or vanillylmandelic acid (VMA) has been described previously for the screening of neuroblastoma (11).
Preparation of monoclonal antibodies to vanillylmandelic acid and homovanillic acid.
Vanillylmandelic acid (VMA) and homovanillic acid (HVA) correspond to the two major urinary metabolites of both epinephrine (E) and norepinephrine (NE) for VMA and dopamine for HVA, respectively.
Determination of vanillylmandelic acid, vanillactic acid, and homovanillic acid in dried urine on filter-paper discs by high-performance liquid chromatography with coulometric electrochemical detection for neuroblastoma screening.
For 15 years, we have determined urinary vanillylmandelic acid (VMA) by a method [1] that relies on the reaction of extracted VMA with the diazo derivative of p-nitroaniline to give a pink chromophore; the chromophore undergoes a bathochromic shift in the presence of an aprotic solvent and a base to give a blue derivative with maximum absorbance at 600 nm.
Simple and rapid liquid-chromatographic method for the simultaneous measurement of vanillylmandelic acid and homovanillic acid [Tech Brief].
8) and 10 patients previously diagnosed as having pheochromocytoma [on the basis of high urinary vanillylmandelic acid (VMA) excretion].
3) Nonstandard abbreviations: NM, normetanephrine; M, metanephrine; GC, gas chromatography; MS, mass spectrometry; and VMA, vanillylmandelic acid.