vanillylmandelic acid


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vanillylmandelic acid

 [vah-nil″il-man-del´-ik]
VMA; the primary end-product of catecholamine metabolism excreted in the urine. Urinary VMA levels are used in screening patients for pheochromocytoma.

va·nil·lyl·man·del·ic ac·id (VMA),

(vă-nil'il-man-del'ik as'id),
Misnomer for 4-hydroxy-3-methoxymandelic acid (α,3-dihydroxy-2-methoxybenzeneacetic acid); the major urinary metabolite of adrenal and sympathetic catecholamines (for example, from both epinephrine and norepinephrine); elevated in most patients with pheochromocytoma.

va·nil·lyl·man·del·ic ac·id

(VMA) (vă-nil'il-man-del'ik as'id)
The major urinary metabolite of adrenal and sympathetic catecholamines; elevated in most patients with pheochromocytoma.
References in periodicals archive ?
[4] Nonstandard abbreviations: TH, tyrosine hydroxylase; L-dopa, L-dihydroxyphenylalanine; B[H.sub.4], tetrahydrobiopterin; THD, tyrosine hydroxylase deficiency; CSF, cerebrospinal fluid; 5-HIAA, 5-hydroxyindoleacetic acid; HVA, homovanillic acid; MHPG, 3-methoxy-4-hydroxy-phenylglycol; and VMA, vanillylmandelic acid.
Preparation of monoclonal antibodies to vanillylmandelic acid and homovanillic acid.
[4] Nonstandard abbreviations: DA, dopamine; HVA, homovanillic acid; VMA, vanillylmandelic acid; KLH, keyhole limpet hemocyanin; OVA, ovalbumin (chicken egg); IR, infrared; and ECSO, concentration of the inhibitor at a B/Bo value of 50% in an inhibition curve.
Vanillylmandelic acid (VMA) and homovanillic acid (HVA) correspond to the two major urinary metabolites of both epinephrine (E) and norepinephrine (NE) for VMA and dopamine for HVA, respectively.
Determination of vanillylmandelic acid, vanillactic acid, and homovanillic acid in dried urine on filter-paper discs by high-performance liquid chromatography with coulometric electrochemical detection for neuroblastoma screening.
Production and characterisation of antibodies to vanillylmandelic acid. J Immunol Methods 1989; 118:101-7.
For 15 years, we have determined urinary vanillylmandelic acid (VMA) by a method [1] that relies on the reaction of extracted VMA with the diazo derivative of p-nitroaniline to give a pink chromophore; the chromophore undergoes a bathochromic shift in the presence of an aprotic solvent and a base to give a blue derivative with maximum absorbance at 600 nm.
Densitometric determination of urinary 4-hydroxy-3-methoxymandelic acid (vanillylmandelic acid).
(3) Nonstandard abbreviations: NM, normetanephrine; M, metanephrine; GC, gas chromatography; MS, mass spectrometry; and VMA, vanillylmandelic acid.
To rule out neuroblastoma MIBG scan was performed and was negative and urine vanillylmandelic acids (VMA) were also negative.