valproic acid


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Related to valproic acid: Divalproex, Sodium valproate

valproic acid

 [val-pro´ik]
an anticonvulsant administered orally for the control of seizures, particularly absence seizures. Serious hepatotoxicity has occurred during valproic acid therapy, so that liver function tests should be performed periodically during treatment.

valproic acid

/val·pro·ic ac·id/ (-ik) an anticonvulsant used particularly for the control of absence seizures.

valproic acid

(văl-prō′ĭk)
n.
An anticonvulsive drug, C8H15NaO2, given orally and by injection to treat epilepsy.

valproic acid

[valprō′ik]
an anticonvulsant.
indications It is prescribed alone or in combination to treat complex partial seizures, absence seizures occurring alone or in combination with other types of seizures, mania associated with bipolar disorder, and migraine prophylaxis.
contraindications It is not recommended for use during pregnancy or lactation. Hepatic disease or dysfunction, urea cycle disorders, and known hypersensitivity to this drug prohibit its use.
adverse effects Among the more severe adverse effects are decreased platelet function and hepatotoxicity, and pancreatitis. GI disturbances are common. Alopecia, rash, headache, and insomnia also may occur. A sometimes fatal hyperammonemic encephalopathy has occurred in patients with known or suspected urea cycle disorders.

valproic acid

Depakote®, Divalproex, Valproate Neurology An anticonvulsant monotherapy for absence seizures, equivalent to carbamazepine for generalized tonic-clonic seizures Adverse effects Weight gain, hair loss, tremors Complications Pancreatitis, cholecystitis. See Seizures. Cf Carbamazepine.

valproic acid

An inhibitor of the enzyme histone deacetylase which helps to maintain HIV in a latent state in people treated with highly active retroviral therapy. Valproic acid. There is hope that this will prove effective in eradicating the virus. Valproic acid has been widely used as an ANTICONVULSANT drug used to prevent all kinds of epileptic seizures. The drug is on the WHO official list. A brand name is Convulex.

valproic acid

an anticonvulsant.
References in periodicals archive ?
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).
The result from this experiment correlates with this by showing that GFAP markers in both retinoic acid and retinoic acid with valproic acid conditions increased compared to the control group.
Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.
At therapeutic plasma concentrations, >90% of valproic acid is bound to proteins, and this fraction is not pharmacologically active.
3] with 28% segmented neutrophils and 40% band forms and a valproic acid level of 113 [micro]g/ml.
This postulates that valproic acid or a metabolite of valproic acid, such as [DELTA]-2-valproate, which may be a more potent inhibitor of the GABA-degrading enzyme than valproic acid, could cause a transient inhibitory effect on dopaminergic pathways.
It is thought that the main mechanism of action of valproic acid which is another antiepileptic drug is related with strengthening of the GABAergic pathways.
Thus, there were 45,669 VA patients over age 65 with dementia diagnosed during 1998-2009 who were on one of the medications under scrutiny: haloperidol, olanzapine, quetiapine, risperidone, valproic acid, or a nontricyclic antidepressant.
Ten patients on valproic acid therapy of any age group with idiopathic or secondary epilepsy, who presented with encephalopathic symptoms, were registered and followed up during the study.
Electronic Auction: Supply of medicinal product for medical use for 2018: Valproic acid in favor of citizens for the purpose of their social security at the expense of the federal budget.
The first drug that came into focus as having dose-dependent teratogenicity in pregnancy is the epilepsy drug valproic acid.