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valproic acid/val·pro·ic ac·id/ (-ik) an anticonvulsant used particularly for the control of absence seizures.
An anticonvulsive drug, C8H15NaO2, given orally and by injection to treat epilepsy.
indications It is prescribed alone or in combination to treat complex partial seizures, absence seizures occurring alone or in combination with other types of seizures, mania associated with bipolar disorder, and migraine prophylaxis.
contraindications It is not recommended for use during pregnancy or lactation. Hepatic disease or dysfunction, urea cycle disorders, and known hypersensitivity to this drug prohibit its use.
adverse effects Among the more severe adverse effects are decreased platelet function and hepatotoxicity, and pancreatitis. GI disturbances are common. Alopecia, rash, headache, and insomnia also may occur. A sometimes fatal hyperammonemic encephalopathy has occurred in patients with known or suspected urea cycle disorders.
valproic acidDepakote®, Divalproex, Valproate Neurology An anticonvulsant monotherapy for absence seizures, equivalent to carbamazepine for generalized tonic-clonic seizures Adverse effects Weight gain, hair loss, tremors Complications Pancreatitis, cholecystitis. See Seizures. Cf Carbamazepine.
valproic acidAn inhibitor of the enzyme histone deacetylase which helps to maintain HIV in a latent state in people treated with highly active retroviral therapy. Valproic acid. There is hope that this will prove effective in eradicating the virus. Valproic acid has been widely used as an ANTICONVULSANT drug used to prevent all kinds of epileptic seizures. The drug is on the WHO official list. A brand name is Convulex.