Sialadenosis caused long-term Valproate
Of the children exposed to valproate
, 7 of 69 children had some kind of a major congenital malformation, and 12 of 58 children had a decreased IQ, compared with the mother.
Both drugs have more favorable pharmacokinetics and do not bind significantly to plasma proteins or influence hepatic metabolism, and no clinically significant adverse effects of vigabatrin and levetiracetam in combination with sodium valproate
have been reported (2, 3, 7, 10).
Table 1 shows the mean of headache severity before treatment as well as half an hour, one hour, and two hours after treatment in the sodium valproate
and Sumatriptan groups, separately.
and its related impurities working standard solution containing 200 [micro]g/mL were prepared in a 100 mL volumetric flask by dissolving 20.0 mg each in 25 mL acetonitrile:water (50:50) and then diluting to volume with the same diluent.
These findings confirm earlier data and support the accepted practice of avoiding the prescription of valproate
for women of reproductive potential, if at all possible.
It is distinctive in our case that the patient has been having hepatotoxicity since a year after starting valproate
as evidenced by dark urine with no other adverse effects until then.
In June 2011, the FDA issued an alert when interim results of this study found that at age 3 years, children exposed to valproate
had lower scores on cognitive tests, information that was added to the labels at that time.
"Children of women who used valproate
during pregnancy had a higher risk of autism spectrum disorder and childhood autism compared with children of women who did not use valproate
," the researchers wrote.
More than one in 10 (12%; 6 out of 50) children whose mums had taken valproate
alone during their pregnancy had a neurodevelopmental problem, as did one in seven (15%; 3 out of 20) of those whose mums had taken valproate
with other drugs.
Inhibition of ureagenesis by valproate
in rat hepatocytes.
Taken together, these findings suggest a lack of awareness of the teratogenic risks of valproate
and topiramate, said the investigators, led by Hyunmi Kim, MD, PhD, MPH, of the department of neurology at Stanford (Calif.) University.