valacyclovir


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valacyclovir

 [val″a-si´klo-vir]
an ester of acyclovir, to which it is metabolized; used as the hydrochloride salt as an antiviral agent in treatment of genital herpes and herpes zoster in patients who are not immunocompromised, administered orally.

valacyclovir

(văl′ə-sī′klō-vîr′)
n.
A nucleoside analog, C13H20N6O4, that is a prodrug of acyclovir and is used in its hydrochloride form to treat herpes simplex and herpes zoster infections.

valacyclovir

Valtrex® Infectious disease An antiviral used for 1st episode/recurrent genital herpes and acute herpes zoster, which may ↓ risk of CMV infection after renal transplantation. See Dofetilide, Herpes simplex.

Valacyclovir

An oral antiviral drug that is available under the trade name Valtrex. The drug blocks the replication of the varicella zoster virus.
Mentioned in: Shingles
References in periodicals archive ?
Valacyclovir is a prodrug metabolized to acyclovir in the liver, 90 percent of which is subsequently excreted in the urine [2].
Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract.
The primary endpoint--the number of swabs that tested positive for HSV-2 relative to the total number of swabs collected--was 2.4% during pritelivir treatment and 5.3% during valacyclovir treatment, a significant difference (relative risk, 0.42).
Our patient responded well to one injection each of ganciclovir and dexamethasone followed by oral valacyclovir although he presented with less than severe involvement of the peripheral retina and moderate vision loss.
Van Toi et al., "Valacyclovir for herpes simplex encephalitis," Antimicrobial Agents and Chemotherapy, vol.
Valacyclovir works by rapidly converting to acyclovir to activate interference of viral DNA synthesis (Vallerand et al., 2017).
"My go-to treatment for uncomplicated zoster is 1 gram of valacyclovir three times a day for 7-10 days, and I throw in either gabapentin or pregabalin."
"My go-to treatment for uncomplicated zoster is 1 gram of valacyclovir three times a day for 7-10 days, and I throw in either gabapentin or pregabalin." Mild pain during the acute phase can be handled with acetaminophen or nonsteroidal anti-inflammatories.
The pivotal study 007 will compare FV-100 to valacyclovir (Valtrex) with the reduction in the incidence of shingles-associated pain, PHN, as a primary endpoint.
In the new study, scientists pitted pritelivir against the first-line herpes drug valacyclovir, marketed as Valtrex, in 91 patients.
HOLLYWOOD, FLA.--A 4-month course of the oral antiviral agent valacyclovir boosted cognition in herpes simplex virus-1-seropositive patients with bipolar disorder and cognitive impairment in a randomized, double-blind placebo-controlled clinical trial.