valaciclovir


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Related to valaciclovir: Valtrex

valaciclovir

An antiviral drug used to treat genital herpes and SHINGLES. Like ACICLOVIR, the drug is a DNA polymerase inhibitor. Research has shown that a daily dose of 500 mg of this drug reduces the risk of transmission of genital herpes by 75 percent. A brand name is Valtrex.
References in periodicals archive ?
Although the available therapies for HSV have increased in use over the past 2 decades and have been successful for reducing genital lesions, treatment with daily valaciclovir has been associated with only a 48% reduction in the risk of sexual transmission of genital herpes.
Oral acyclovir, valaciclovir, and famciclovir are recommended to reduce the duration and severity of recurrent genital herpes.
Products based on antiviral substances such as aciclovir, penciclovir, famciclovir and valaciclovir are the most commonly used treatment options.
500 mg Duration of 3 weeks 5 months therapy Co-medication Labetolol, fosinopril, Valaciclovir, verapamil, metformin, pseudo-ephedrine, and insulin, aspirin, and ibuprofen aminosalicylic acid Co-morbidity Polymyositis, diabetes n.
Acyclovir (ACV), valaciclovir, famciclovir, and cidofovir have been used for the treatment of HSV infection and associated diseases (Cassady and Whitley, 1997).
Presently, the only aspect of the HSV life cycle for which antiviral therapy has been successfully developed is the process of DNA replication, which is targeted by a small group of nucleoside analogues that include acyclovir (ACV), valaciclovir, penciclovir, and famciclovir.
Products based on antiviral substances such as acyclovir, penciclovir, famciclovir and valaciclovir are the most commonly used treatment options.
preclinical study showed that Famvir(R) (famciclovir, SmithKline Beecham), when administered during initial herpes simplex virus (HSV) infection, was more effective than valaciclovir (Valtrex(R), Glaxo Wellcome) in reducing the number of cells containing latent (dormant) HSV even when treatment was delayed for several days.
Current formulary reimbursement restrictions on valaciclovir could be overturned if generic rivals to Valtrex were launched at a dramatic discount rather than the commonly applied practice of charging highest achievable price, replacing acyclovir as the most popular drug in the process.
Famciclovir is characterized by high bioavailability of 77 percent, compared to 55 percent and 15 percent for valaciclovir and acyclovir, respectively.
5 /PRNewswire/ -- A new study shows that famciclovir is significantly more effective than valaciclovir (the prodrug of acyclovir) in reducing viral replication during treatment and also in suppressing viral replication following treatment in a mouse model designed to simulate herpes simplex virus infection in the immunocompromised patient.
Valaciclovir is the next generation antiherpes product from Wellcome.