In the heart the dominant action of [alpha]2-AR agonists is decrease in tachycardia (Through blocking cardioaccelerator nerve) and bradycardia via [alpha]2A-AR (Through a vagomimetic
In addition, SSS occurred just after the administration of vagomimetic anesthetic drugs, fentanyl and vecuronium, which was reported to cause SSS and is the most plausible cause in this scenario .
If not, then vagomimetic anesthetic drugs must be used with caution to avoid hypervagotonic activity to the SA node.
Presynaptically mediated inhibition of norepinephrine and a vagomimetic
action at nucleus tractus solitarius are responsible for bradycardia, but no bradycardia was seen in both groups in our study.
Ipecac administration is relatively contraindicated following ingestion of cardiotoxic, highly vagomimetic
plants that can cause nausea, vomiting, and bradycardia; often progressing to bradydysrhythmias, conduction blocks, and ventricular tachydysrhythmias.
Because of its sympatholytic and vagomimetic
actions, dexmedetomidine is approved with a warning about hypotension, bradycardia and sinus arrest and can be used only in a monitored situation.
Decrease in sympathetic tone by central action, norepinephrine inhibition pre-synaptically mediated and vagomimetic
action at nucleus tractus solitarius by Clonidine is accountable for bradycardia.
Clonidine reduces heart rate by stimulating presynaptic [alpha]2 receptors present in medulla and hypothalamus which decreases sympathetic out flow and partly by a vagomimetic
In the heart, the dominant action of 2-AR agonists is a decrease in tachycardia (through blocking cardioaccelerator nerve) and bradycardia via 2A-AR (through a vagomimetic
The juice of bulbs of Allium cepa may have a mechanism of action like digoxin and a brief cardiac arrest at a high dose which may be due to vagomimetic
effect like digoxin.