A-OK medication regimen  Atropine 1 mg (vagolytic
) Ondansetron 8 mg (5-HT3 antagonist) Ketorolac 30 mg (cyclooxygenase inhibitor)
test (atropine test) was done, and sinus bradycardia attributed to a hypervagotonic state induced by 5-FU.3 Transient asymptomatic bradycardia associated with infusional 5-FU in 6 patients has also been reported by Talapatra K et al 2007 again from India.4 It may have certain pharmacogenomic basis and possibly have a typical ethnic distribution in the subcontinent and/or South Asia
Previous studies have shown an unacceptable incidence of bradycardia associated with the use of remifentanil in the absence of a vagolytic
As regards changes in cardiac rhythm, we must mention the occurrence of sinus tachycardia - a frequent rhythm during anesthesia, not necessarily related to the superficial plane of anesthesia but may be compensatory to severe hypotension, or result from the use of vagolytic
drugs or catecholamine (NUNES, 2002).
Disopyramide is a class I anti-arrhythmic agent that has additional effects of negative inotropy and a vagolytic
Disopyramide administration is limited by vagolytic
side-effects including dry mouth, exacerbation of prostatism and it should not be initiated in patients with narrow-angle glaucoma, prostatism or impaired LV systolic function (3,47).
Pancuronium bromide has been shown to exhibit vagolytic
activity in mammals (Melnikov et al., 1999), but to our knowledge its effect on shark heart rates is unknown and would depend on the resting vagal tone.
If the bronchitis patient has a spasmodic cough with bronchial constriction, a disinfectant substance might be recommended like essential oil of thyme, considered "vagolytic
" by French phytotherapy doctors.
In addition to blocking [Na.sup.+] and [K.sup.+] channels, it is weakly vagolytic
and has [alpha]-adrenergic blocking properties.
effect as seen in Rocuronium may help in prevention of intraoperative bradycardia with certain anaesthetic agents.
Four patients in mephentermine group had one or more readings of heart rate below 60 beats/minute, but none of these patients required treatment with vagolytic
This is consistent with the study of Neeti M and colleagues, (8) who attributed it to the weak vagolytic
property of rocuronium.