neoplasia (ne?o-pla'zh(e-)a) [ neo- + -plasia]
The development of neoplasms (new tissues or tumors).
anal intraepithelial neoplasia Abbreviation: AIN
A precancerous change in the squamous cells of the anus that may eventually develop into anorectal cancer. It is similar to cervical intraepithelial neoplasia in that it is a premalignant lesion that arises in squamous cells, is found primarily in sexually active people, and is associated with human papillomavirus and HIV. Synonym: anal dysplasia; anal squamous intraepithelial lesion
cervical intraepithelial neoplasia Abbreviation: CIN
Dysplasia of the basal layers of the squamous epithelium of the uterine cervix. This may progress to involve deeper layers of the epithelium. Grades 1, 2, and 3 represent increasing progression of the pathological process. Grade 3 (CIN 3) represents carcinoma in situ. CIN 3 is also classed stage 0 of cancer of the cervix. See: Bethesda System, The; cervical cancer
Abnormal cell growth that is found within epithelial cells but has not yet spread to neighboring, underlying, or distant tissues. Intraepithelial neoplasia is thought to be an early marker of some cancers, e.g., cancers of the breast, prostate, or uterine cervix. See: cervical intraepithelial neoplasia
multiple endocrine neoplasia Abbreviation: MEN
Any of several inherited syndromes caused by a defect in tumor suppressor genes that produces benign and malignant tumors of many endocrine glands. Angiofibromas and collagenomas of the skin also are common findings. This group of diseases has been classed according to the glands affected. Synonym: multiple endocrine neoplasm
multiple endocrine neoplasia, type I Abbreviation: MEN I
Multiple endocrine neoplasia in which there are tumors of the parathyroid, pituitary, and islet cells of the pancreas. Synonym: Wermer syndrome
multiple endocrine neoplasia, type II
Multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia. Synonym: Sipple syndrome
multiple endocrine neoplasia, type III
Multiple endocrine neoplasia that is similar to MEN II but in which there are marked facial aberrations with neuromas of the conjunctiva, labial mucosa, tongue, larynx, and gastric intestinal tract.
vaginal intraepithelial neoplasia Abbreviation: VAIN
Vulvar intraepiethelial neoplasia.
vulvar intraepithelial neoplasia Abbreviation: VIN
Synonym: vaginal intraepithelial neoplasia
Precancerous, noninvasive lesions of the squamous epithelium of the vulva.
Symptoms are vulvar pain, itching, or burning. Risk factors include exposure to Human Papilloma Virus 16 and 18, type 2 Herpes Simplex Virus, and smoking.
Diagnosis is made by biopsy of the lesion.
Treatments include brief observation to see if the condition spontaneously remits, topically applied chemotherapy, laser ablation, or wide surgical excision.