vaginal intraepithelial neoplasia


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vaginal intraepithelial neoplasia

preinvasive squamous cell carcinoma (carcinoma in situ) limited to vaginal epithelium; like vulvar or cervical intraepithelial neoplasia, graded histologically on a scale from 1 to 3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papillomavirus infection; may progress to invasive carcinoma.

vag·i·nal in·tra·ep·i·the·li·al ne·o·pla·si·a

(vaj'i-năl in'tră-ep'i-thē'lē-ăl nē'ō-plā'zē-ă)
Preinvasive squamous cell carcinoma (carcinoma in situ) limited to vaginal epithelium; like vulvar or cervical intraepithelial neoplasia, graded histologically on a scale from 1-3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papillomavirus infection; may progress to invasive carcinoma.

neoplasia

(ne?o-pla'zh(e-)a) [ neo- + -plasia]
The development of neoplasms (new tissues or tumors).

anal intraepithelial neoplasia

Abbreviation: AIN
A precancerous change in the squamous cells of the anus that may eventually develop into anorectal cancer. It is similar to cervical intraepithelial neoplasia in that it is a premalignant lesion that arises in squamous cells, is found primarily in sexually active people, and is associated with human papillomavirus and HIV.
Synonym: anal dysplasia; anal squamous intraepithelial lesion

cervical intraepithelial neoplasia

Abbreviation: CIN
Dysplasia of the basal layers of the squamous epithelium of the uterine cervix. This may progress to involve deeper layers of the epithelium. Grades 1, 2, and 3 represent increasing progression of the pathological process. Grade 3 (CIN 3) represents carcinoma in situ. CIN 3 is also classed stage 0 of cancer of the cervix.
See: Bethesda System, The; cervical cancer

intraepithelial neoplasia

Abnormal cell growth that is found within epithelial cells but has not yet spread to neighboring, underlying, or distant tissues. Intraepithelial neoplasia is thought to be an early marker of some cancers, e.g., cancers of the breast, prostate, or uterine cervix. See: cervical intraepithelial neoplasia

multiple endocrine neoplasia

Abbreviation: MEN
Any of several inherited syndromes caused by a defect in tumor suppressor genes that produces benign and malignant tumors of many endocrine glands. Angiofibromas and collagenomas of the skin also are common findings. This group of diseases has been classed according to the glands affected. Synonym: multiple endocrine neoplasm

multiple endocrine neoplasia, type I

Abbreviation: MEN I
Multiple endocrine neoplasia in which there are tumors of the parathyroid, pituitary, and islet cells of the pancreas.
Synonym: Wermer syndrome

multiple endocrine neoplasia, type II

Multiple endocrine neoplasia characterized by medullary thyroid carcinoma, pheochromocytoma, and parathyroid hyperplasia.
Synonym: Sipple syndrome

multiple endocrine neoplasia, type III

Multiple endocrine neoplasia that is similar to MEN II but in which there are marked facial aberrations with neuromas of the conjunctiva, labial mucosa, tongue, larynx, and gastric intestinal tract.

vaginal intraepithelial neoplasia

Abbreviation: VAIN
Vulvar intraepiethelial neoplasia.

vulvar intraepithelial neoplasia

Abbreviation: VIN
Precancerous, noninvasive lesions of the squamous epithelium of the vulva.

Symptoms

Symptoms are vulvar pain, itching, or burning. Risk factors include exposure to Human Papilloma Virus 16 and 18, type 2 Herpes Simplex Virus, and smoking.

Diagnosis

Diagnosis is made by biopsy of the lesion.

Treatment

Treatments include brief observation to see if the condition spontaneously remits, topically applied chemotherapy, laser ablation, or wide surgical excision.

Synonym: vaginal intraepithelial neoplasia
References in periodicals archive ?
The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN).
Vaginal intraepithelial neoplasia was present at some resection margins.
In addition, cases of vulvar and vaginal intraepithelial neoplasia (VIN 2/3 and VaIN 2/3) were the efficacy endpoints to assess prevention of HPV-related vulvar and vaginal cancers, and observations of external genital lesions were the efficacy endpoints for the prevention of genital warts.
A series of 84 patients at a student health service has been treated for vaginal intraepithelial neoplasia (VAIN) with the topical immune response modifier.
81) If a hysterectomy is performed for microinvasive or invasive disease, care must be taken to assess the vaginal cuff so that vaginal intraepithelial neoplasia (VAIN) is not missed and inadvertently incorporated into the suture lines.
1 percent of HPV 6-, 11-, 16- or 18-related external genital lesions, including genital warts, vulvar intraepithelial neoplasia (VIN) or vaginal intraepithelial neoplasia (VaIN).
Vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN) are not uncommon in women with HIV infection, and they often develop concurrently with high-grade cervical lesions.