Using light microscopy, histological features such as vacuolation
, spongiform changes, astrocytic gliosis and amyloid plaques can generally be observed.
These lesions were characterised by infiltration of inflammatory cells, vacuolation
of myelin sheaths and axons and abnormal morphology of neurons.
The contents of the neuron then deteriorate, leaving an intact membrane still bound to outside structures and filled with membranous residuals of cellular material; this is the process of vacuolation
Brain biopsy showed myelin and axonal loss, with vacuolation
in the white matter and reactive astrocytosis.
Root meristem cells showed increased vacuolation
of the cytoplasm after exposure to excess nitrogen or Al; swelling of cellular membranes was observed after exposure to the highest [O.
Infected prions can damage brain tissue through a process of vacuolation
, making neurons appear like sponges with pitted holes, thus the term spongiform.
The changes observed included vacuolation
, irregular spindle shapes, lack of cell aggregates and occasional pyknosis.
Degeneration in the stomach and hepatocyte vacuolation
were observed in rats following 6 months of dosing at systemic exposure values at least 179 times the human exposure based on the AUC of the recommended daily human dose.
Microscopic examination of skin lesions showed swelling, vacuolation
, and characteristic eosinophilic cytoplasmic inclusion bodies in the stratified squamous epithelial cells of the folliculus pili (online Technical Appendix Figure 1, http://wwwnc.
It is known that ooplasmic vacuolation
and GC pyknosis are observed simultaneously with early antrum formation in atretic follicles (21, 33).
Liponeurocytoma is a circumscribed tumor of the cerebellum (Figure 4), composed of small neurocytic cells, some of which have prominent cytoplasmic vacuolation
The histopathological study of the brain showed neuronal losses and vacuolation
in brain tissues,  reported neuron necrosis in different region of the brain in mice.