The animal in this report had motor neurological deficits as well as vacuolation
and demyelination of the white matter of the central and peripheral nervous system, without a concomitant inflammatory and/or neoplastic process.
In the rats treated with pioglitazone (Group C and Group D), the tubular lesions were significantly reduced compared with Group B, concerning dilatation in Group C and Group D (P=0.01), vacuolation
in Group C (P=0.02) and in Group D (P=0.01), and apoptosis in Group D (P=0.01).
Ultrastructural evaluation of the aortae of the untreated OVX rats fed with TPO diet revealed early intimal lesions such as endothelial vacuolation
, the presence of hooklike cytoplasmic process, and widening of the subendothelial space filled with massive amount of granular substances, as described by Still & O'Neal, 1962.
Histopathological examination revealed mild-to-moderate diffuse cytoplasmic vacuolation
of the cortical cells of the adrenal glands (involving the zona fasciculata and zona reticularis) in male (6/10) and female (8/10) animals of the 720 mg/kg bw/day group, although these lesions were not detected in satellite groups at the end of the recovery period.
For example, if degenerating nonsegmented neutrophils were misidentified as young neutrophils (bands and metamyelocytes), the differential count would appear to show a "left shift." Together with vacuolations
in the cytoplasm, the smear may be incorrectly interpreted as "toxic," a sign of bacterial infection.
Rats received APAP, CUR and THQ showed a marked improvement in hepatic degeneration which was restricted to few hepatocytes with mild vacuolation
of their cytoplasm while the nuclei appear normal.
Caption: FIGURE 7: Peripheral smear at time of second relapse: Neoplastic cells show more pronounced nuclear irregularities with variable cytoplasmic vacuolation
Again, new questions turn fundamental: [C] do the ependymoma subtypes analysed herein constitute a fat-storage metabolic cell imbalance and a degenerative vacuolation
Tubules showed vacuolation
and degeneration and necrosis of epithelial cells.
In ARF model group, many necrotic tubules with casts, tubular dilation, and vacuolation
were seen (Figure 4(b)).
They found that spermidine increased the permeability of the blood-retinal barrier and induced the vacuolation
, atrophy, and death of RPE cells.
As shown in Figure 1, the histological tissue sections of the Con group showed normal liver histological morphology after H&E staining, while the C[Cl.sub.4] induced Mod group exhibit abnormal histopathological changes, with significant vacuolation
and degenerative changes in liver, ballooning, and fatty changes of hepatocytes and inflammatory cell infiltration.