Comparison of Histologic Features of Various Causes of Advanced Pulmonary Fibrosis Feature IPF CTD-ILD Distribution of fibrosis Peripheral, Mixed peripheral paraseptal and centrilobular Fibrotic NSIP-like areas Variable Frequent Interface between fibrosis Distinct Indistinct and preserved parenchyma Fibroblast foci Numerous Variable Smooth muscle metaplasia in Frequent Uncommon fibrosis Pleuritis Rare Frequent, often with adhesions Lymphoid hyperplasia Rare Frequent, often with germinal centers Peribronchiolar metaplasia Variable, mild Frequent, may be and focal extensive Interstitial granulomas Absent Absent Histiocytic infiltrates Absent Absent Vacuolated
or clear type 2 Absent Absent pneumocytes and macrophages Feature Chr.
Moreover, the lumenae of the seminiferous tubules were more deflated, folded and vacuolated
in the hinny.
This is due to the apparent breakdown and loss of AG cells, which are replaced by vacuolated
areas, or empty spaces surrounded by connective tissue fibers, or else remnants of cell membranes (Fig.
B1, B2, and B3 represent STZ-diabetic group of rats and showed disturbance of the acinar pattern structure, pyknotic nuclei of some acini cells (black arrow) with severe damage; dilation and thickening of blood vessels (dashed arrow) and congestion of the blood vessels (red arrow) and vacuolated
acini (green arrow).
2,6,7) In lipoid cell variant of urothelial carcinoma, the vacuolated
cells show CK and CK7 positivity (Table 1), indicating their epithelial nature.
The cytoplasm was eosinophilic and vacuolated
with a mucin-filled matrix.
jarbua, these alterations included vacuolated
hepatocytes, fatty change, adipocytes, vacuolated
foci, inflammatory response, degeneration of hepatocytes, sinusoidal dilation and frank necrosis were noted in fish specimen collected from Al-Kumrah site as shown in figures (5a,b-6a,b).
1) Necrosis of individual cells and vacuolated
histiocytes scattered in the parenchyma produce a starry sky effect within the neoplasm.
For example, while the stratum corneum is relatively dry and holds between 10 to 15% water; the living epidermis is the sub-tissue that holds water in the skin (40-50%) and the vacuolated
dermis can contain even more water.
In contrast, Antoni B areas demonstrate more loosely arranged vacuolated
The intima was rich in large vacuolated
cells having central round basophilic nucleus, with abundant foamy cytoplasm in H and E stained sections.
The cells had a large nucleus and showed variable sebaceous differentiation manifested as finely vacuolated
or foamy cytoplasm (Figures 3 and 4).