The ducts and surface are similarly lined by variably
vacuolated cuboidal to columnar cells and mucus cells that are thought to secrete neutral mucopolysaccharides (Andrews 1988) (Fig.
Vacuolated cells were present in 10(20.8%) of radicular cysts and were not seen in any of the OKC.
(8) However, several histological patterns are recognized including acinar, intercalated ductal,
vacuolated, clear and non-specific glandular and solid-lobular, microcystic, papillary-cystic and follicular growth patterns.
Notice many hepatocytes with
vacuolated cytoplasm (V).
(c) The Leydig cell tumor is composed of polygonal cells with prominent nucleoli with eosinophilic, granular, and
vacuolated cytoplasm (H&E, x4000).
The morphology consists of a solid, nested, or tubular pattern of cells with a
vacuolated eosinophilic to clear cytoplasm.
In the immunohistochemical study, carcinoembryonic antigen and EMA are negative whereas
vacuolated cells are positive for adipophilin (10).
Moreover, extraskeletal myxoid chondrosarcoma was considered in the differential diagnosis; however, due to the absence of a cell population with
vacuolated cytoplasm and chondromyxoid matrix, this entity was excluded.
On MRI, the tumor will be lobulated, intermediate to hypointense on T1W, and very hyperintense on T2W, secondary to the high fluid content of
vacuolated cellular components.
Pulmonary involvement in HPS is characterized by accumulation of ceroid lipofuscin within the lung, manifested by the presence of clear,
vacuolated, ceroid-laden type 2 pneumocytes and alveolar macrophages (Figure 7, B through D) that are typically found in a background of prominent interstitial fibrosis.
Vacuolated and dyskeratotic keratinocytes are also typically present within the epidermal invagination.
The underlying keratinocytes are large and
vacuolated (1).
