f) Few
vacuolated cells (None within 8mm of central cornea).
The DiffQuik-stained (A) and Papanicolaou-stained (B) smears demonstrate the presence of cohesive malignant epithelial cell clusters exhibiting finely to overtly
vacuolated cytoplasm.
These defects included;
vacuolated degeneration of the spermatogenic cells, presence of necrotic cells inside the degenerative tubule, aspermatogenesis (Fig.
29) Xanthoma has been defined as a discrete mass of highly
vacuolated macrophages and multinucleated giant cells, while xanthomatosis has been defined as a similar process but lacking discrete margins and often situated in the skin.
Both lesions may present as solitary, dome-shaped, firm nodules, but the latter contains increased blood vessels with dilated lumina, fibroblastic stroma with stellate or multinucleated atypical cells, numerous hair follicles surrounded by collagen fibers, and
vacuolated clear cells in the epidermis, which often shows slight acanthosis.
At the middle phase of previtellogenic oocytes, the activity of these few nucleoli is high, and the nucleoli are
vacuolated.
Some cells were markedly enlarged and completely
vacuolated.
3) The nucleus is large and peripherally placed, with small nucleoli, and the cytoplasm may be granular or
vacuolated because of the presence of glycogen.
Histology revealed sheets and trabeculae of malignant cells in lower dermis with variation in size, eosinophilic and clear
vacuolated cytoplasm with enlarged hyper chromatic nucleus, prominent nucleoli and abnormal mitotic figures.
On higher magnification, marked nuclear pleomorphism, conspicuous nucleoli, and prominently
vacuolated cytoplasm were appreciated; there was variability to the extent of cytoplasmic vacuolization, which ranged from fine vacuoles to large vacuoles (Figure 1, B).
In fact, certain histologic appearance can be similar to the signet ring cell, such as
vacuolated lymphocytes and altered smooth muscle cells after radiotherapy or hormone therapy.
perivascular inflammation, periappendageal inflammation, and collagen damage, some cases had complete effacement of the sebaceous glands with their replacement with well formed granulomas comprising of lymphocytes, many epithelioid cells, few neutrophils and giant cells along with
vacuolated macrophages containing lipid droplets derived from sebaceous glands.
