vaccinia


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Related to vaccinia: smallpox, cowpox, molluscum contagiosum

vaccinia

 [vak-sin´e-ah]
the cutaneous and sometimes systemic reactions associated with vaccination with smallpox vaccine. See also cowpox and paravaccinia.
vaccinia gangreno´sa generalized vaccinia with failure to develop antibodies against the virus (due to agammaglobulinemia), with spreading necrosis at the site and metastasis of lesions throughout the body.
generalized vaccinia a condition of widespread vaccinial lesions resulting from sensitivity response to smallpox vaccination and delayed production of neutralizing antibodies.
progressive vaccinia vaccinia gangrenosa.

vac·cin·i·a

(vak-sin'ē-ă),
An infection, primarily local and limited to the site of inoculation, induced in humans by inoculation with the vaccinia virus, type species in the genus Orthopoxvirus (family Poxviridae) to confer resistance to smallpox. On about the third day after this vaccination, papules form at the site of inoculation, which are transformed into umbilicated vesicles and later pustules; they then dry up, and the scab falls off on about the 21st day, leaving a pitted scar; in some cases there are more or less marked constitutional disturbances. Because of the global elimination of smallpox, routine vaccination is not now practiced.
[L. vaccinus, relating to a cow, fr. vacca, a cow]

vaccinia

(văk-sĭn′ē-ə)
n.
1. See cowpox.
2. The usually mild, cutaneous and sometimes systemic reaction in individuals who have been inoculated with smallpox vaccine.

vac·cin′i·al adj.

vaccinia

[vaksin′ē·ə]
Etymology: L, vaccinus
an infectious disease of cattle caused by a poxvirus that may be transmitted to humans by direct contact or deliberate inoculation as a vaccine against smallpox. A pustule develops at the site of infection, usually followed by malaise and fever that last for several days. After 2 weeks the pustule becomes a crust that eventually drops off, leaving a scar. Satellite lesions may occur, and the virus may be spread to other sites by scratching. Individuals with eczema or other preexisting skin disease may develop generalized vaccinia. Rarely, a severe encephalitis follows vaccinia. Also called cowpox. Compare smallpox. See also vaccination.
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Vaccinia

vac·cin·i·a

(vak-sin'ē-ă)
An infection, primarily local and limited to the site of inoculation, induced in humans by inoculation with the vaccinia virus, type species in the genus Orthopoxvirus to confer resistance to smallpox. Because of the global elimination of smallpox, routine vaccination is not now practiced.
[L. vaccinus, relating to a cow, fr. vacca, a cow]

vaccinia

A mild disease, acquired from the udders of cows, that causes blisters on the hands but no significant general upset. The disease is of historic importance. From knowledge of it, Edward Jenner developed vaccination against SMALLPOX. Also known as cowpox.

vaccinia

the vaccinia virus; a laboratory generated virus, antigenically related to the cowpox virus, that causes a lesion on the teat skin of affected cows. It is indistinguishable from cowpox lesions and used to be used to vaccinate humans against smallpox.
References in periodicals archive ?
Pexa-Vec was derived from vaccinia, which has been used for decades as a vaccine in healthy individuals, and was engineered to selectively target cancer cells.
On the basis of previous studies that detected viral DNA in serum samples (4-6), we used realtime PCR to amplify the highly conserved orthopoxvirus vaccinia growth factor (vgf) gene DNA (P.
Vaccinia virus is best known as the basis of the vaccine that eradicated smallpox.
The team studied how vaccinia virus, when altered to delete the E3L gene, evolved to successfully replicate in the presence of human PKR.
Scientists have known for many years that the well-studied vaccinia poxvirus uses two proteins to inhibit the protein kinase R response.
While these results are very interesting and hopefully may lead to a new weapon against the HIV pandemic, they are preliminary and it is far too soon to recommend the general use of vaccinia immunisation for fighting HIV," the team said.
He eventually recovered, but subsequent test results showed he had suffered from vaccinia virus infection that did not match the type of virus strain used in experiments in the laboratory where he worked.
The tumor-targeting vaccinia virus known as JX-594 was injected directly into subjects' tumors every three weeks.
The study reported here reveals that both cultured cells and tissue specimen had vaccinia virus infectivity persistent for [less than or equal to]5 days at all tested temperatures when stored in RNAlater.
ATLANTA -- No cases of fetal vaccinia or increases in pregnancy losses have been found after smallpox vaccination during pregnancy, according to an interim analysis of data from the National Smallpox Vaccine in Pregnancy Registry.
has reported that studies performed in collaboration with the National Institutes of Health (NIH) in Bethesda, MD, show that AusAm's lead antiviral drug candidate, DES6, inhibits the replication and spread of vaccinia virus in tissue culture.