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Related to vaccina: cowpox, vaccinia virus


the cutaneous and sometimes systemic reactions associated with vaccination with smallpox vaccine. See also cowpox and paravaccinia.
vaccinia gangreno´sa generalized vaccinia with failure to develop antibodies against the virus (due to agammaglobulinemia), with spreading necrosis at the site and metastasis of lesions throughout the body.
generalized vaccinia a condition of widespread vaccinial lesions resulting from sensitivity response to smallpox vaccination and delayed production of neutralizing antibodies.
progressive vaccinia vaccinia gangrenosa.


An infection, primarily local and limited to the site of inoculation, induced in humans by inoculation with the vaccinia virus, type species in the genus Orthopoxvirus (family Poxviridae) to confer resistance to smallpox. On about the third day after this vaccination, papules form at the site of inoculation, which are transformed into umbilicated vesicles and later pustules; they then dry up, and the scab falls off on about the 21st day, leaving a pitted scar; in some cases there are more or less marked constitutional disturbances. Because of the global elimination of smallpox, routine vaccination is not now practiced.
[L. vaccinus, relating to a cow, fr. vacca, a cow]


vaccinia virus.
References in periodicals archive ?
Although the patient had been vaccinated against smallpox >20 years ago, a serum sample isolated 6 years before the accident showed a level of vaccina virus-specific IgG antibodies approximately 2 times higher than the level in naive persons.
Researchers discovered that a protein called N-WASP determines how fast the vaccina virus - the virus used as a vaccine to eradicate smallpox - moves.
coli, salmonella, listeria, staph, strep, pseudomonas, Norwalk-like virus (FCV), Influenza A, Hepatitis B and C, vaccina (smallpox stimulant) and a broad range of other fungi and viruses, as well as TB and resistant bacteria, while being completely safe to use.
Enhancement of FIP in cats immunize with vaccina virus recombinants expressing CCV and TGEV spike glycoproteins.