AKT2

(redirected from v-akt murine thymoma viral oncogene homolog)

AKT2

A gene on chromosome 19q13.1, which encodes a protein of the subfamily serine/threonine kinases containing SH2 (Src homology 2)-like domains, and phosphorylates several known proteins.

Molecular pathology
The gene is amplified and overexpressed in some primary ovarian tumours and pancreatic ductal carcinomas.
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6] Human genes: EGFR, epidermal growth factor receptor; KRAS, Kirsten rat sarcoma viral oncogene homolog; TP53, tumor protein p53; NF2, neurofibromin 2 (merlin); AKT1, v-akt murine thymoma viral oncogene homolog 1; BRAF, B-Raf proto-oncogene, serine/ threonine kinase; NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; KMT2D, lysine (K)-specific methyltransferase 2D; NSD1, nuclear receptor binding SET domain protein 1; CREB3L1, cAMP responsive element binding protein 3-like 1; TPR, translocated promoter region, nuclear basket protein; TSC2, tuberous sclerosis 2.
5] Human genes: AKT1, v-akt murine thymoma viral oncogene homolog 1; EGFR, epidermal growth factor receptor; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF, v-raf murine sarcoma viral oncogene homolog B1; TP53, tumor protein p53; PDGFRA, platelet-derived growth factor receptor, [alpha] polypeptide.
5] Human genes: CBFB, core-binding factor, beta subunit; RUNX1, runt-related transcription factor 1; MAGI3, membrane associated guanylate kinase, WW and PDZ domain containing 3; AKT3, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); MAGI3-AKT3, fusion of genes MAGI3 and AKT3; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; CT-NNB1, catenin (cadherin-associated protein), beta 1, 88kDa; SMARCA4, SWI/ SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; CREBBP, CREB-binding protein; WNT, wingless-type MMTV integration site family; BRAF, v-raf murine sarcoma viral oncogene homolog B1.