KRAS

(redirected from v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)

KRAS

A Kirsten ras oncogene homolog from the mammalian ras gene family on chromosome 12p12.1, which encodes a small GTPase in which a single amino acid substitution results in a transforming protein.

Molecular pathology
The KRAS transforming protein has been linked to various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, colorectal carcinoma, acute myelogenous leukaemia, juvenile myelomonocytic leukaemia, gastric cancer, pilocytic astrocytoma, Noonan syndrome type 3, and cardiofaciocutaneous syndrome
References in periodicals archive ?
To demonstrate the application of LDT-COLD-PCR, we selected a 146-bp v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) [2] amplicon, with a [T.
In their proposal, low-grade serous carcinoma develops from serous epithelium that acquires gene mutations for v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and v-raf murine sarcoma viral oncogene homolog B1 (BRAF).
EGFR, coded by the epidermal growth factor receptor (EGFR) gene, mediates growth proliferation, cell death inhibition, and promotion of invasion by signaling through the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) protein (32).
In particular, miR-129 has 16 predicted target genes [platelet-derived growth factor receptor, alpha polypeptide (PDGFRA); platelet-derived growth factor receptor, beta polypeptide (PDGFRB); epidermal growth factor receptor (EGFR); phospholipase C, gamma 1 (PLCG1), SHC (Src homology 2 domain containing) transforming protein 4 (SHC4); protein kinase C, alpha (PRKCA); protein kinase C, beta (PRKCB); protein kinase C, delta (PRKCD) protein kinase C, epsilon (PRKCE); protein kinase C, iota (PRKCI); growth factor receptor-bound protein 2 (GRB2); son of sevenless homolog 1 (SOS1); SOS2; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS); death-associated protein kinase 1 (DAPK1); DAPK2; DAPK3; and ribosomal protein S6 kinase, 90kDa, polypeptide 5 (RPS6KA5) (also known as MSK1)].
4] Human genes: EGFR, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian; RPP30, ribonuclease P/MRP 30kDa subunit; PIK3CA, phosphoinositide-3-kinase, catalytic, alpha polypeptide; MET, met proto-oncogene (hepatocyte growth factor receptor); KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.