Research generated from the registry will examine risk factors, genetics, epidemiology, treatment cost-effectiveness and real-world outcomes from a database of patients with uveal
The researchers found that all three patients developed uveal
effusion within one to two months after initiation of anti-PD-1 and anti-PD-L1 monoclonal antibody therapy.
"I refer them for uveal
, kidney, and /or lung cancer evaluation and see them back two to four times a year for skin checks."
The exact reasons for such differences in response to treatment between uveal
and mucosal melanoma subtypes remain unclear.
Canovas et al., "Atypically low spontaneous sister chromatid exchange formation in uveal
melanoma," Genes, Chromosomes and Cancer, vol.
Logan et al., "Molecular pathways mediating liver metastasis in patients with uveal
melanoma," Clinical Cancer Research, vol.
Gok et al., "Endoresection of large uveal
melanomas: Clinical results in a consecutive series of 200 cases," British Journal of Ophthalmology, vol.
Our patient with this metastatic uveal
melanoma with extensive liver metastases with GNQ-209P mutation on the tissue biopsy (Figures 3 and 4) and undetectable mutations on the peripheral blood molecular profiling in serial follow-up samples suggests marked response to nabpaclitaxel.
Immunocare, a UK-based pharma firm dedicated to the development of biological drugs for cancer, infectious diseases and autoimmune diseases, recruited 19 metastatic uveal
melanoma patients for its intra-patient dose escalation Phase I IMCgp100 study.
(7) The condition is relatively common, having been described in 2.1% of eyes at autopsy and nearly 1% of eyes removed with uveal
Clinically, the main concern about nevi is to distinguish them from uveal