2004), and BPF also had uterotropic
(estrogenic) effects in female rodents and gonadotropic (androgenic) effects in male rodents (Higashihara et al.
24) Zhu et al (1998) assessed the activity of Rosmarinus officinalis on oestrogen clearance activity as well as uterotropic
action in CD-1 ovariectomised mice.
4 times its effective dose did not evoke estrogenic response in uterus, suggesting considerable uterine safety, however at the 200 mg/kg dose, it showed mild uterotropic
effect (Supplementary Table 1).
71) In animals, there may be a uterotropic
response in immature rats treated with raloxifene after ovariectomy, (73) and long-term studies are needed in humans to fully evaluate the effect of raloxifene on the endometrium.
As was published in Cancer Research on May 15, 2001, in an animal model, 6-MCDF, in combination with Tamoxifen, synergistically inhibits mammary tumor growth and also blocks the uterotropic
effects of Tamoxifen.
Effect of halogenated hydrocarbon insecticides on the metabolism and uterotropic
action of estrogens in rats and mice.
2003) and, also shown previously and in the present study, CR BNO 1055 exerts no uterotropic
Gene expression changes in the immature rat uterus: effects of uterotropic
and sub-uterotrophic doses of bisphenol A.
effects of dietary equol administration in ovariectomized Sprague-Dawley rats.
Methoxychlor is uterotropic
in the ovariectomized rat and can cause adverse developmental and reproductive effects in mice and rats (Alm et al.
In the first step of the present study the uterotropic
potential of silymarin has been evaluated.
bioassay for estrogenicity in neonates.