Misoprostol, a prostaglandin E1 analogue was used in obstetrics because of its uterotonic
and cervical ripening effects in different studies (7, 10).
Instead, the critical component of the AMTSL package appears to be administration of a uterotonic
, as reported in a large WHO-directed multicenter clinical trial published in 2012.
The 80% fibrous tissue and 20% smooth-muscle component of the cervix has poor contractility, and it is therefore predisposed to haemorrhage with poor response to uterotonic
Careful administration of uterotonic
agents is necessary as these have marked haemodynamic effects (11,12).
For PPH prevention and treatment uterotonic
therapy is key.
such as oxytocin, not controlled traction on the cord, is the most important component of a managed third stage, says the editorial.
plants and their bioactive constituents.
Misoprostol, a uterotonic
drug that contracts the uterus and ripens the cervix, has been approved by the World Health Organization (WHO) (1) for the treatment of incomplete abortion and included in WIlO's priority medicines list for mothers and children.
After reviewing all of the pharmacological and clinical studies--more than 500 scientific publications over the past ten years--on DMT and 5-methoxy-DMT (a substance similar to DMT that is sometimes found in the ayahuasca mixture), it can be asserted that not a single study exists, either in animals or humans, that examines the teratogenic, embryotoxic or uterotonic
effects of DMT or 5-MeO-DMT.
Further, the uterotonic
, molluscidal, hepatoprotective, anxiolytic and sedative activities of various extracts of the plant have also been reported [10,11,12,13].
The physiological third stage involves supporting the woman's physiology during the third stage, with the major and important difference that a prophylactic uterotonic
is not given and controlled cord traction is not used (NZCOM, 2006).
This increased expression of OXTR renders the uterine environment more sensitive to the uterotonic
effect of oxytocin (OXT).