uteroglobin


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u·ter·o·glo·bin

(yū'tĕr-ō-glō'bin), [MIM*192020]
A steroid-inducible, evolutionarily conserved, homodimeric secreted protein with many biologic activities including a proinflammatory effect, inhibition of soluble lipoprotein-lipase A2, and chemotaxis of neutrophils and monocytes. It binds to several putative receptors on several cell types and inhibits cellular invasion of the extracellular matrix. It is found in blood and urine, uterus and numerous other tissues, but not kidneys. In mice, uteroglobin has been shown to bind to fibronectin (Fn), preventing Fn self-aggregation and subsequent abnormal tissue deposition, especially in glomeruli. It is essential for maintaining normal renal function in mice.
Synonym(s): blastokinin

u·ter·o·glo·bin

(yū'tĕr-ō-glō'bin)
Steroid-inducible, evolutionarily conserved, homodimeric secreted protein with many biologic activities including a proinflammatory effect, inhibition of soluble lipoprotein-lipase A2, and chemotaxis of neutrophils and monocytes. It binds to several putative receptors on several cell types and inhibits cellular invasion of the extracellular matrix. It is found in blood and urine, the uterus, and numerous other tissues, but not the kidneys.
Synonym(s): bastokinin.
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References in periodicals archive ?
Expression of SV40 T antigen under control of rabbit uteroglobin promoter in transgenic mice.
Clara cell secretory protein of 10-16 kDa (CC16), also known as CC10, Club cell protein, CCSP, or uteroglobin [9,10], a member of the secretoglobin family [11], is the most abundant protein in bronchoalveolar lavage (BAL) fluid or tracheal aspirates (TA) from neonates [12,13].
Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer.
Clara cell 10-kDa protein (CC10 also known as CC16 SCGB1A1 uteroglobin) is a 10-kDa protein produced by non-ciliated Clara cells and is one of the most abundant proteins in the fluids lining the airways.2 The CC10 gene is located on chromosome
Long-term (12 or more wk) ovariectomized rabbits require treatment with PRL and then P4 for secretion of uteroglobin by uterine epithelia.
Bioactive peptides derived from uteroglobin. Ann N Y Acad Sci 2000; 923:128-40.
The crystal structure of Fel d 1 revealed that the allergen was homologous to uteroglobin and contained an internal, asymmetric, amphipathic ligand binding pocket (Kaiser et al.
Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11g13.
The lung's uteroglobin protein seemed to have no opening through which a PCB or a metabolite could enter to dock at internal binding sites, explains Torlief Haerd of the Karolinska Institute in Huddinge.
Adner et al., "Gene profiling reveals increased expression of uteroglobin and other antiinflammatory genes in glucocorticoid-treated nasal polyps" Journal of Allergy and Clinical Immunology, vol.
These results not only theoretically confirmed the clinical relevance between profilin and polcalcin [45], but also suggested the relevant relationship between 2 EF-hand calcium-binding proteins (P59747 [33]) and Poa p IX/Phl p VI allergen family (Q40237 [34]), cereal trypsin/alpha-amylase inhibitor family (P16968 [36]), nonspecific lipid-transfer protein (O04404 [35]), and even uteroglobin (P30438 [37]) and Ole e 1 (O82015 [17]).
Mammaglobin, a highly glycosylated low-molecularweight protein, is a homolog of rabbit uteroglobin and rat steroid-binding protein subunit C3 (1, 2) and is a member of the uteroglobin family with yet unknown functions.