uteroglobin


Also found in: Wikipedia.

u·ter·o·glo·bin

(yū'tĕr-ō-glō'bin), [MIM*192020]
A steroid-inducible, evolutionarily conserved, homodimeric secreted protein with many biologic activities including a proinflammatory effect, inhibition of soluble lipoprotein-lipase A2, and chemotaxis of neutrophils and monocytes. It binds to several putative receptors on several cell types and inhibits cellular invasion of the extracellular matrix. It is found in blood and urine, uterus and numerous other tissues, but not kidneys. In mice, uteroglobin has been shown to bind to fibronectin (Fn), preventing Fn self-aggregation and subsequent abnormal tissue deposition, especially in glomeruli. It is essential for maintaining normal renal function in mice.
Synonym(s): blastokinin

u·ter·o·glo·bin

(yū'tĕr-ō-glō'bin)
Steroid-inducible, evolutionarily conserved, homodimeric secreted protein with many biologic activities including a proinflammatory effect, inhibition of soluble lipoprotein-lipase A2, and chemotaxis of neutrophils and monocytes. It binds to several putative receptors on several cell types and inhibits cellular invasion of the extracellular matrix. It is found in blood and urine, the uterus, and numerous other tissues, but not the kidneys.
Synonym(s): bastokinin.
Mentioned in ?
References in periodicals archive ?
Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer.
The following key words and subject terms were searched: Clara cell 10-kDa protein CC10 CC16 SCGB1A1 uteroglobin asthma genetic and polymorphism.
Long-term (12 or more wk) ovariectomized rabbits require treatment with PRL and then P4 for secretion of uteroglobin by uterine epithelia.
Interactions between PRL and P4 increase endometrial proliferation and uteroglobin secretion in long-term ovariectomized rabbits and hyperprolactinemic pigs have more total recoverable uteroferrin, glucose and PGF in uterine flushings (Young et al.
The crystal structure of Fel d 1 revealed that the allergen was homologous to uteroglobin and contained an internal, asymmetric, amphipathic ligand binding pocket (Kaiser et al.
Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11g13.
The lung's uteroglobin protein seemed to have no opening through which a PCB or a metabolite could enter to dock at internal binding sites, explains Torlief Haerd of the Karolinska Institute in Huddinge.
Indeed, notes coauthor Johan Lund, the only natural compound known to bind to uteroglobin is the hormone progesterone.
Mammaglobin, a highly glycosylated low-molecularweight protein, is a homolog of rabbit uteroglobin and rat steroid-binding protein subunit C3 (1, 2) and is a member of the uteroglobin family with yet unknown functions.
Identification of mammaglobin B, a novel member of the uteroglobin gene family.
27) Polymorphisms in a number of genes such as uteroglobin (which has anti-inflammatory/immunomodulatory properties), TNF-[beta]*2, human leukocyte antigen (HLA) B54 (HLAB54), CFTR, lymphotoxin a (LTA), transforming growth factor [beta] (TGFB1), IL-1 receptor agonist (TL1RN), IL-22, [alpha]-1 antitrypsin, mesenchymal-epithelial transition (MET), and [beta]2 adrenoceptor (ADRB2) have also been observed in CRS patients.
76) Genetic analysis had initially ruled out a role for the fibronectin, desmin, villin, and uteroglobin genes.