The trial assessed the effect of nolasiban on uterine contractions and endometrial blood flow, both of which are known to be associated with uterine receptivity
and embryo implantation, and ultimately pregnancy and live birth following IVF.
The multifaceted actions of leukaemia inhibitory factor in mediating uterine receptivity
and embryo implantation.
The expression and distribution of the focal adhesion proteins in the rat uterine epithelial cells are associated with uterine receptivity
(Kaneko et al., 2008).
 On reproductive system, BPA exerts toxic effect on uterine endometrial proliferation, uterine receptivity
associated with implantation failure in animals.
Abnormal uterine artery velocimetry is associated with unexplained sub-fertility, poorer uterine receptivity
to implantation, and recurrent miscarriages (5, 6).
Song, "Lessons from mouse models to understand uterine receptivity
for embryo implantation," Korean Journal of Fertility and Sterility, vol.
Lininger, "Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity
in women," Reproductive Biology and Endocrinology, vol.
The changes in endometrium may be regarded as a reflection of endometrial proliferation under the influence of ovarian steroid hormones and cytokines.6 Ultrasound measurement of endometrial thickness by trans-vaginal scan (TVS) is a simple and reproducible method to evaluate endometrial proliferation and has been studied as a possible indicator of uterine receptivity
in fresh IVF cycles.4,5,7,8
Clinical evidence for a detrimental effect on uterine receptivity
of high serum estradiol levels in high responder and normal responder patients.
Increase in BMI causes collective impairment of a number of processes coupled with oocyte production, development, maturation, fertilization, endometrial development, uterine receptivity
and implantation necessary for continuation of pregnancy3.
In species such as mice, uterine LIF displays biphasic expression pattern with the first peak appearing in the glands in preparation for uterine receptivity
while the second peak appears in the stroma surrounding the implanting blastocyst at the time of attachment reaction .
Many factors such as genetic abnormalities of embryos, defects in uterine receptivity
, uterine contractions, expulsion of embryos, blood or mucus on the catheter tip, bacterial contamination of the catheter, and retained embryos have all been associated with problematic and unsuccessful embryo transfers (2).