usherin

usherin

(ŭsh'ĕr-in),
A possible protein component of the basal lamina and extracellular matrix of the cochlea encoded by the gene for Usher type 2A syndrome. It may be involved in cellular adhesion.
References in periodicals archive ?
Expression of usherin in the anthozoan Nematostella vectensis.
Los tres genes mas comunmente implicados en la RP son: RHO (25% de la RP autosomica dominante); USH2A tambien conocido como Usherin (20% de la RP autosomica recesiva); RPGR (regulador de la retinitis pigmentosa GTPasa) 70 a 80% de la RP; y el gen EYS que fue identificado recientemente como el responsable de la RP autosomica recesiva en el locus RP25.
One of the genes responsible for Usher Syndrome II encodes the protein usherin (Eudy et al, 1998; Bhattacharya et al, 2002).
Finally, we examined representative metazoan genomes and found highly conserved usherin genes throughout the deuterostome lineage as well as in some protostomes.
The nN2A Nematostella usherin plasmid was selected to generate probes for in situ hybridization.
vectensis sequences encoding predicted proteins with an architecture similar to portions of vertebrate usherin were found using the program Superfamily 1.
This matches precisely the domain organization of the N-terminal two-thirds of the protein usherin in vertebrates.
Usherin is expressed in gastrulae, planulae, and polyps
This novel stretch represents an exon predicted to be an intron, as it encodes an open reading frame with 44% similarity to an exon found in the corresponding FN3 domain of usherin from Branchio-stoma ftoridae (alignment not shown).
In situ hybridization with an usherin-specific riboprobe (nN2A) confirms that usherins are expressed both in planulae and in juvenile polyps (Fig.
The domain organization of Nematostella usherin is highly conserved