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Protective role of thiols in cyclophosphamide-induced urotoxicity and depression of hepatic drug metabolism.
Long-term oral CYC therapy is associated with substantial urotoxicity in 25% of patients [1], including the development of urothelial carcinoma of the urinary bladder.
Patients treated with ifosfamide were assumed to receive concomitant treatment with mesna to prevent urotoxicity. Patients receiving gemcitabine plus docetaxel were assumed to receive treatment with lenograstim to prevent neutropenic complications; those with prior pelvic irradiation were assumed to receive a 25% dose reduction of gemcitabine plus docetaxel [33].
Keywords: Cyclophosphamide; Urotoxicity; Histopathology; Allyl isothiocyanate; Phenyl isothiocyanate
Administrations of higher doses of CTX produce severe urotoxicity with hemorrhagic cystitis on urinary bladder (Hutter et al., 1969).
Here we studied the effect of two naturally occurring isothiocyanates such as allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC), on the inhibition of cyclophosphamide-induced urotoxicity.
Determination of the effect of naturally occurring isothiocynates on CTX-induced urotoxicity
One of the major side effects of CTX administration is urotoxicity in which urinary bladder is severely affected with continued therapy.
somnifera, commonly known as 'Aswagandha' could effectively cure the urotoxicity induced by CTX administration (Davis and Kuttan, 2000).
Morphological, histopathological, biochemical and enzyme analysis showed that the naturally occurring isothiocyanates, AITC and PITC could alleviate the severe urotoxicity induced by CTX.