Placental S100, uroplakin
2, and uroplakin
3 are other emerging urothelial markers.
Immunohistochemical study revealed total loss of INI-1 expression (figure 4); positive staining of vimentin (figure 5), panCK (figure 6), CK19 (figure 7), and PAX8; and negative staining of CK7, CK20, p63, uroplakin
, CD 10, and 34BE12 (figure 8).
Concmonoclonal IHC antibodies Uroplakin
II (Clone BC21)
2 In addition, ovarian TCCs are negative for CK20, Thrombomodulin (TM) and uroplakin
III, which are the antigens that are usually (CK20) or sometimes (TM and uroplakin
III) detected in bladder TCCs.
III and E-cadherin were also detected (Fig.
The cells expressed a very unique protein and marker of bladder cells called uroplakin
, which makes the bladder impermeable to toxins in the urine.
III staining was found in 6 of 12 tumours (50%).
High expression of human uroplakin
la in urinary bladder transitional cell carcinoma.
Kerr, then at the Agriculture Department, attached the genetic sequence for human growth hormone to the uroplakin
gene promoter, which controls where and when the gene switches on.
coli from binding to uroplakin
1a and 1b receptors.
5) Metastases from the urinary tract express thrombomodulin, uroplakin
III, CK7 and CK20.
We also produced anti-human uroplakin
Ia antibody and showed its usefulness as a specific histologic marker because of its stable expression even in metastatic lesions (25).