urokinase-type plasminogen activator


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Related to urokinase-type plasminogen activator: Plasminogen activator inhibitor

Abbokinase

A proprietary formulation of urokinase, a thrombolytic that activates the fibrinolysis by increasing plasmin production from plasminogen, thereby degrading fibrin clots, fibrinogen, and other clotting factors.

urokinase-type plasminogen activator

Abbreviation: uPA
A protein that degrades extracellular tissues. It has been linked to the spread of some cancers by invasion and metastasis.
See also: activator
References in periodicals archive ?
A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease," Kidney International, vol.
Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients.
Protein kinase activity-dependent inhibition of urokinase-type plasminogen activator gene transcription by cyclic AMP in human pre-B lymphoma cell line RC-K8.
Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells.
In situ gene expression of urokinase-type plasminogen activator and its receptor in transitional cell carcinoma of the human bladder.
11] Human genes: Try, trypsinogen; MMP2/7/9, matrix-metalloproteinase2/-7/-9; uPA, urokinase-type plasminogen activator; uPAR, urokinase-type plasminogen activator receptor; MSH2, Mut S homolog 2; GAPD, glyceraldehyde-3-phosphate dehydrogenase.
Elevation of serum levels of urokinase-type plasminogen activator and its receptor is associated with disease progression and prognosis in patients with prostate cancer.
2]-terminal domain of the cellular receptor for human urokinase-type plasminogen activator.
Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin.
Urokinase-type plasminogen activator (uPA) is a serine protease that catalyzes the conversion of plasminogen to plasmin, an active enzyme that is able to degrade various extracellular matrix proteins and to activate MMPs and growth factors (3).
Proteolytic cleavage of urokinase-type plasminogen activator by stromelysin-1 (MMP-3).
Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals.