urokinase


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Related to urokinase: streptokinase

urokinase

 [u″ro-ki´nās]
u-plasminogen activator; the term is used particularly to denote a pharmaceutical preparation of the enzyme, administered intravenously as a thrombolytic agent in the treatment of acute coronary thrombosis and acute pulmonary embolism; also used to clear intravenous catheters of obstructions composed of clotted blood or fibrin deposits.

plas·min·o·gen ac·ti·va·tor

a proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former.
Synonym(s): urokinase

urokinase

/uro·ki·nase/ (UK) (u″ro-ki´nās) u-plasminogen activator; an enzyme in the urine of humans and other mammals, elaborated by the parenchymal cells of the human kidney and acting as a plasminogen activator. It is used as a therapeutic thrombolytic agent.

urokinase

(yo͝or′ō-kī′nās, -nāz)
n.
An enzyme originally found in human urine that catalyzes the conversion of plasminogen to plasmin and is used in medicine to dissolve blood clots.

urokinase

[yoo͡r′əkī′nās]
an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

Abbokinase

A proprietary formulation of urokinase, a thrombolytic that activates the fibrinolysis by increasing plasmin production from plasminogen, thereby degrading fibrin clots, fibrinogen, and other clotting factors.

urokinase

A fibrinolytic enzyme involved in extracellular proteolysis; it is more active during cell migration and tissue remodeling, and cleaves fibronectin. See Kringle domain. Cf Streptokinase, Reteplase, tPA.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase.

urokinase

An enzyme found in human urine that is used as a drug to dissolve blood clots occurring within blood vessels. A PLASMINOGEN activator.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase.

urokinase (yoor´ōkī´nās),

n an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

urokinase

an enzyme found in the urine of humans and other mammals which is secreted by kidney parenchymal cells and converts plasminogen to plasmin and activates the fibrinolytic system; used as a fibrinolytic agent.
References in periodicals archive ?
The soluble urokinase receptor is not a clinical marker for focal segmental glomerulosclerosis," Kidney International, vol.
Comparison of urokinase and video-assisted thoracoscopic surgery for treatment of childhood empyema.
Randomised controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism.
Intrapulmonary artery infusion of urokinase for treatment of massive pulmonary embolism: a review of 26 patients with and without contraindications to systemic thrombolytic therapy.
The problem with using either of these to replace urokinase in hemodialysis catheters was that neither had been tested ['or use in opening occluded catheters.
Improved financial performance is providing the company with the increased flexibility it needs to shape a suitable distribution agreement for its urokinase product line.
Data from 12 RCTs, involving three drugs (streptokinase, urokinase and recombinant tissue plasminogen activator) and fewer than 4000 subjects, are currently available.
He has trouble seeing to one side and he walks with a cane, but he's a rancher, and he's back doing what ranchers do,'' eight months after the drug urokinase was administered to dissolve the clot and restore healthy blood flow to the brain, Clark said.
It involves injecting a thrombolytic (clot-dissolving) agent, such as streptokinase, urokinase, or TPA (tissue plasminogen activator), to dissolve a clot in a coronary artery and restore some blood flow.
It is interesting that both TPA and urokinase occur endogenously in the human endometrium, which normally has plasminogen activator activity.