urokinase


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to urokinase: streptokinase

urokinase

 [u″ro-ki´nās]
u-plasminogen activator; the term is used particularly to denote a pharmaceutical preparation of the enzyme, administered intravenously as a thrombolytic agent in the treatment of acute coronary thrombosis and acute pulmonary embolism; also used to clear intravenous catheters of obstructions composed of clotted blood or fibrin deposits.

plas·min·o·gen ac·ti·va·tor

a proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former.
Synonym(s): urokinase

urokinase

/uro·ki·nase/ (UK) (u″ro-ki´nās) u-plasminogen activator; an enzyme in the urine of humans and other mammals, elaborated by the parenchymal cells of the human kidney and acting as a plasminogen activator. It is used as a therapeutic thrombolytic agent.

urokinase

(yo͝or′ō-kī′nās, -nāz)
n.
An enzyme originally found in human urine that catalyzes the conversion of plasminogen to plasmin and is used in medicine to dissolve blood clots.

urokinase

[yoo͡r′əkī′nās]
an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

Abbokinase

A proprietary formulation of urokinase, a thrombolytic that activates the fibrinolysis by increasing plasmin production from plasminogen, thereby degrading fibrin clots, fibrinogen, and other clotting factors.

urokinase

A fibrinolytic enzyme involved in extracellular proteolysis; it is more active during cell migration and tissue remodeling, and cleaves fibronectin. See Kringle domain. Cf Streptokinase, Reteplase, tPA.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase.

urokinase

An enzyme found in human urine that is used as a drug to dissolve blood clots occurring within blood vessels. A PLASMINOGEN activator.

plas·min·o·gen ac·ti·va·tor

(plaz-min'ŏ-jen ak'ti-vā-tŏr)
A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase.

urokinase (yoor´ōkī´nās),

n an enzyme produced in the kidney and found in urine that is a potent plasminogen activator of the fibrinolytic system. A pharmaceutic preparation of urokinase is administered intravenously in the treatment of pulmonary embolism.

urokinase

an enzyme found in the urine of humans and other mammals which is secreted by kidney parenchymal cells and converts plasminogen to plasmin and activates the fibrinolytic system; used as a fibrinolytic agent.
References in periodicals archive ?
Circulating soluble urokinase plasminogen activator receptor Is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients.
In the present study, our initial comparison between commercially available thrombolytic drugs indicated that only 2 drugs, urokinase and alteplase, were able to salvage clotted specimens such that the yield of metaphase cells was sufficient for routine clinical analysis (Table 1).
Our early experience with alteplase has demonstrated that it is an effective alternative to urokinase in catheter-directed thrombolysis for peripheral vascular occlusion; however, it is clear that further investigation is warranted in order to determine its optimal dose.
The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients.
Comerota, one received intracatheter urokinase and six were treated with rt-PA.
Among the group treated only with urokinase therapy, 74.
In the previously published clinical series in which urokinase was administered for IVH lysis, posthemorrhagic hydrocephalus requiring shunting varied from as high as 55%, reported by Rohde et al, (38) and 33.
Expression of urokinase plasminogen activator, its receptor and type-1 inhibitor in malignant and benign prostate tissue.
The three agents in this category are anistreplase (Eminase) and streptokinase (Streptase), both rated C, and urokinase (Abbokinase).
In most of the trials, tPA has broken upclots significantly faster and more frequently than the traditional clot-busting medicines: streptokinase, a bacterial enzyme; and urokinase, an enzyme found in the urine, Burton E.
Framework agreement with a single operator per lot for provision of medicines Urokinase Raltitrexed, Entecavir and Somatostatin for Service Organizations Osakidetza