In malaria patients from Colombia, hemoglobinuria (86%), urobilinuria (66%), proteinuria (54%), hematuria (43%), and bilirubinuria (39%) were associated with dark urine; renal dysfunction was identified in these patients .
Present in 147 (24.3%) of 605 patients, bilirubinuria was associated with urobilinuria, proteinuria, and increased specific gravity (P < 0.05).
Urobilinuria was identified in 184 (30.6%) of 602 patients; it was associated with higher bilirubin in urine and proteinuria (P < 0.05).
This alteration was associated with bilirubinuria, urobilinuria, blood, and increased specific gravity (P < 0.05) and was related to higher serum BUN, TB, DB, ALT, and aspartatetransaminase (AST) values and lower platelet counts.
falciparum cases showed higher frequency of ketonuria, proteinuria, and urobilinuria (P < 0.005, Chi-square test).
The most common urinalysis alterations in the 620 malaria patients were increased specific gravity (41.2%), proteinuria (39.2%), urobilinuria (30.6%), blood (29.8%), bilirubinuria (24.3%), ketones (22.7%), and leukocytes (14.86%).
In our patients, proteinuria was associated with increased TB and DB serum levels, with increased risk of liver, kidney, and lung complications, and other alterations in urinalysis including bilirubinuria, urobilinuria, ketonuria, and glycosuria.
Associations were found among serum ALT and bilirubinuria (P = 0.01), urobilinuria (P = 0.006), and proteinuria (P = 0.001); this contributes to explaining a relationship between liver complication and bilirubinuria (OR 2.1, CI 1.3-3.3), urobilinuria (OR 2.7, CI 1.7-4.5), and proteinuria (OR 1.5, CI 1.0-2.3).