In the prostodin group, glomerular hypertrophy and vascular dilation were noted and urinary space declined, in a way that in some points in glomeruli network, Bowman capsule was seen due to increased size in vicinity of external wall (Figure 2).
Marouane et al found that treatment with vanadium caused damage to the kidneys, in a way that vanadium led to glomerular hypertrophy, decreased urinary space in kidney nephrons' Bowman capsule, and increased serum creatinine through inducing lipid peroxidation and increasing serum creatinine.
Biochemical and histopathologic investigations of this study indicated that prostodin caused increased blood serum creatinine and urea and Bowman capsule diameter, decreased urinary space, as well as glomerular dilation (glomerular hypertrophy), resulting in disorder in renal function, lack of proper blood treatment, and finally further increase in serum creatinine.
EGb reduced diabetes-induced morphological alterations of the kidney such as increase in volume of glomeruli, capillary tufts, urinary space, and thickening of Bowman's capsule basement membrane.
The diabetes-induced enlargement of many glomeruli, capillary tufts and of the subcapsular urinary space is obviously less expressed in the EGb-treated diabetic group (Fig.