9 in patients receiving urate-lowering drugs, especially uricosuric drugs, and in patients with uric acid nephrolithiasis to increase the solubility of uric acid in urine.
The treatment for these patients should be individualized with inhibitors of urate production or uricosuric drugs.
The pharmacologic treatment of acute gout attacks may use non-steroidal anti-inflammatory drugs, colchicine or corticoids, while chronic therapy uses inhibitors of the uric acid synthesis (allopurinol or febuxostat), uricosuric drugs
that favour the elimination of the uric acid (probenecid, benziodarone or sulfinpyrazone) or uricase derivatives (rasburicase, pegloticase).
Thus, it is important to carefully evaluate the extent of disease burden (ie, gout symptoms and effect on quality of life) and determine whether the patient has taken ULT and uricosuric drugs
as prescribed before considering this option.
Moreover, uricosuric drugs
are not effective in patients who have impaired renal function.
7) Uricosuric drugs
are more popular outside the United States.
Renal impairment, which renders uricosuric drugs
The patient requires prevention of malignancy-associated hyperuricemia and tumor lysis syndrome due to cytolytic therapy for hematologic malignancies; the resulting massive uricosuria precludes the use of uricosuric drugs
Folin showed the effect of uricosuric drugs
on blood and uric acid levels in gout; introduced the colorimetric method for measuring epinephrine; and published the first normal values for uric acid, nonprotein nitrogen (NPN), and protein in blood.
The failure of uricosuric drugs
to reduce the attack rate in primary non-tophaceous gout.