uricosuric agent


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uricosuric agent

A drug, e.g., probenecid or sulfinpyrazone, that increases the urinary excretion of uric acid by blocking renal tubular absorption, thereby reducing the concentration of uric acid in the blood. It is used to treat gout.

Patient care

Probenecid and sulfinpyrazones are used to treat gout. Side effects of both include headache, gastrointestinal upset, epigastric pain, kidney stone formation, and peptic ulcer. These drugs should be avoided by patients with diminished renal function. Any uricosuric agent should be taken with milk, food, or antacids to reduce gastric distress. Patients should drink large volumes of water. Sodium bicarbonate (or potassium citrate) is prescribed simultaneously with these agents to alkalinize urine and keep uric acid crystals in solution.

See also: agent
References in periodicals archive ?
12) URAT1 blockade is now appreciated to be the mechanism of several currently-prescribed uricosuric agents, including probenecid.
Efficacy and Safety of RDEA594, a Novel Uricosuric Agent, as Combination Therapy with Allopurinol in Gout Patients: Randomized, Double-Blind, Placebo-Controlled, Phase 2 Experience
Aggrenox [R] (aspirin/extended-release dipryidamole) Potential Drug Interactions The following medications are known to have the potential to interact with aspirin: ACE inhibitors, acetazolamide, anticoagulants, anticonvulsants, beta blockers, diuretics, methotrexate, NSAIDs, and oral hypoglycemic and uricosuric agents.
Uricosuric agents, such a probenecid, and the xanthine oxidase inhibitor allopurinol are used for this purpose.