uricosuric agent


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uricosuric agent

A drug, e.g., probenecid or sulfinpyrazone, that increases the urinary excretion of uric acid by blocking renal tubular absorption, thereby reducing the concentration of uric acid in the blood. It is used to treat gout.

Patient care

Probenecid and sulfinpyrazones are used to treat gout. Side effects of both include headache, gastrointestinal upset, epigastric pain, kidney stone formation, and peptic ulcer. These drugs should be avoided by patients with diminished renal function. Any uricosuric agent should be taken with milk, food, or antacids to reduce gastric distress. Patients should drink large volumes of water. Sodium bicarbonate (or potassium citrate) is prescribed simultaneously with these agents to alkalinize urine and keep uric acid crystals in solution.

See also: agent
References in periodicals archive ?
If uric acid levels do not reach the goal of <6 mg/dL (or <5 mg/dL) at the maximum dose of a first-line xanthine oxidase inhibitor, add a uricosuric agent such as probenecid, fenofibrate, or losartan.
The 3e recommendations also address the use of benzbromarone, a uricosuric agent that is not available in the United States.
Efficacy and safety of a range of doses of FDEA594, a novel uricosuric agent, as a single agen in hyperuricemic gout patients: multicenter, randomized, double-blind, placebo-controlled phase 2 experience.
Long-term management may mean taking a maintenance dose of an anti-gout agent or a uricosuric agent to keep the level of uric acid in the blood and joints at a low level.
com) under the titles, "RDEA594, a Novel Uricosuric Agent, Significantly Reduced Serum Urate Levels and Was Well Tolerated in a Phase 2a Pilot Study in Hyperuricemic Gout Patients" and "Evaluation of Drug-Drug Interaction Potential Between RDEA594, Allopurinol and Febuxostat in Preclinical Species.