Losartan has a modest uricosuric
effect and can modestly lower uric acid levels.
Guidelines also recommend adding a uricosuric
agent (lesinurad or probenecid) or switching to a uricosuric
agent (probenecid) if the sUA target level cannot be reached by an appropriate dosage of a xanthine oxidase inhibitor or when a xanthine oxidase inhibitor is not tolerated.
This treatment is recommended to maintain urine pH of 6.2-6.9 in patients receiving urate-lowering drugs, especially uricosuric
drugs, and in patients with uric acid nephrolithiasis to increase the solubility of uric acid in urine.
We prescribed benzbromarone, a potent uricosuric
drug, to treat his gouty arthritis.
In the present study, uric acid levels in urine and FEUA reduced in the PO group compared to the NC group although there are reports demonstrating the uricosuric
effect of PO [33, 34].
Also, patients who had uricosuric
medications use, myeloproliferative neoplasms, congenital disorders involving uric acid metabolisms, or other risk factors of developing uric acid urolithiasis were not surveyed and thus the role of these risk factors remains to be determined in this study.
Benzbromarone, an old uricosuric
drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice.
Angiotensin receptor blockers have a mild uricosuric
effect and may help with lowering uric acid levels.
Hence, for patients suffering from Gout or elderly drugs like Losartan potassium, captopril or Enalapril are preferred as they are effective in treating Hyperuricemia and gout complicated by hypertension because of their combined hypotensive and uricosuric
"Losartan is a weak uricosuric
and can lower the serum urate level slightly, possibly making the addition of another hypouricemic agent unnecessary, while still controlling the blood pressure with a single pill," Dr.
Diuretic, antilithiasic, uricosuric
and antiseptic properties are usually accredited to corn silk, style/stigma of maize (Zea mays L.).
Treatment options may include uricosuric
agents that enhance uric acid excretion, xanthine oxidase inhibitors that decrease urate formation and uricase enzymes that catalyze the conversion to allantoin, a more soluble purine product.