9 in patients receiving urate-lowering drugs, especially uricosuric
drugs, and in patients with uric acid nephrolithiasis to increase the solubility of uric acid in urine.
We prescribed benzbromarone, a potent uricosuric
drug, to treat his gouty arthritis.
Probenecid is a uricosuric
agent and an alternative to allopurinol.
When xanthine oxidase inhibitors fail to achieve the target sUA or cannot be used, uricosuric
medications can be considered.
Mulberroside A possesses potent uricosuric
and nephroprotective effects in hyperuricemic mice.
The pharmacologic treatment of acute gout attacks may use non-steroidal anti-inflammatory drugs, colchicine or corticoids, while chronic therapy uses inhibitors of the uric acid synthesis (allopurinol or febuxostat), uricosuric
drugs that favour the elimination of the uric acid (probenecid, benziodarone or sulfinpyrazone) or uricase derivatives (rasburicase, pegloticase).
sativa is a miraculous plant with countless pharmacological significance including uricosuric
, anti- diabetic, anti-fertility, choleretic, antihistaminic with hepato-protective, anti toxic and anti oxidant properties (Salem, 2005).
The cornerstone of the clinical management of gout is anti-hyperuricemic therapy, either by uricosuric
drugs or by XO inhibitors (XOI), such as allopurinol .
agent probenecid was recognized as an alternative first-line agent for urate lowering in patients who could not tolerate or had a contraindication to at least one xanthine oxidase inhibitor.
The formation of uric acid from purines may be reduced with xanthine-oxidase inhibitors allopurinol or febuxostat, or the use of uricosuric
drug sulfinpyrazone to increase the excretion of uric acid within urine.
The xanthine oxidase (XO) inhibitors are not only useful, but they also possess lesser side effects as compared to uricosuric
and anti-inflammatory agents.
High doses ( greater than 3 gm /day) are uricosuric
, while low doses cause UA retention and hyperuricemia.