Probenecid is a uricosuric
agent and an alternative to allopurinol.
We found that the two steroidal glycosides possesses potent uricosuric
effect in hyperuricemic mice through decreasing renal mURAT1 mainly and inhibiting XOD activity in a certain extent, which are attributable to the enhancement of uric acid excretion and attenuate hyperuricemia-induced renal dysfunction.
Should monotherapy with a xanthine oxidase inhibitor be insufficient to reach target, the TFP recommended the addition of a uricosuric
agent, such as probenecid, losartan, or fenofibrate to the xanthine oxidase inhibitor.
It is a uricosuric
and renal tubular transport-blocking agent.
Many drugs influence the excretion of uric acid and may precipitate acute attacks, while losartan is a good choice in the management of hypertension because of its uricosuric
Among substances having UGT1A1-inhibiting activity is a uricosuric
drug probenecid (77).
In addition to these large trials, the effect of probenecid (a uricosuric
agent with no effect on xanthine oxidase) has been studied in a group with heart failure.
If uric acid levels stay high, the doctor will probably try to lower them with a special drug called a uricosuric
Folin showed the effect of uricosuric
drugs on blood and uric acid levels in gout; introduced the colorimetric method for measuring epinephrine; and published the first normal values for uric acid, nonprotein nitrogen (NPN), and protein in blood.
15) On June 11, 1958, a supplemental NDA for Flexin was submitted for the drug's use as a uricosuric
agent to treat gout.
The launch of lesinurad will provide a new uricosuric
drug positioned to be used in combination with allopurinol," said Decision Resources Analyst Gideon Heap, M.
Losarian is a weak uricosuric
and can lower the serum urate level slightly, possibly making the addition of another hypouricemic agent unnecessary, while still controlling the blood pressure with a single pill," Dr.