We analyzed the following variables: age, BMI (body mass index, kg/m2), creatinine serum (mg/dL), calcium serum (mg/dL), phosphorus serum (mg/dL), phosphatase alkaline serum (U/L), iPTH (intact parathyroid hormone, pg/mL), 25-OH vitamin D (U/L), pH serum, urine pH, 24-hour urine calcium, 24-hour citraturia, 24-hour oxaluria, 24-hour uricosuria
, and calcium/creatinine ratio in urine during fasting.
High doses of vitamin C have been claimed to cause oxalate excretion, kidney stones, uricosuria
, vitamin B12 deficiency, systemic conditioning, and pro-oxidant effects.
They may also have nonnephrotic-range proteinuria, uricosuria
and, at times, renal tubular acidosis.
7) Although the mechanism for protein-mediated urate excretion had not been determined, at least one investigator has suggested that it may be the action of amino acids rather than intact protein, competing as weak acids at renal urate transporters, that acts to block urate uptake and induce uricosuria
The need to prevent malignancy-related hyperuricemia and tumor lysis syndrome due to cytolytic therapy for hematologic malignancies, with massive uricosuria
precluding the use of uricosuric drugs.
However, no evidence of other tubular dysfunction, such as glucosuria, uricosuria
, or bicarbonaturia was noticed in patients with hypokalemia and inappropriate kaliuresis.
On admission, hypouricemia with inappropriate uricosuria
(FE of uric acid >10%), renal phosphate wasting (FE of phosphate >20%), inappropriate kaliuria (FE of potassium >9%), and serum potassium concentrations near the lower limit of the reference interval were found (9, 10).