According to Selecta, this reduced rate of gout flares appears to be substantially lower than the incidence of gout flares reported in clinical trials involving the current FDA-approved uricase
This research applied both adsorption on zeolite and entrapment by [kappa]-carrageenan on the immobilisation of L.plantarum Mar8 producing uricase
. Optimisation experiment and characterisation of both kinetics and stability were carried out to develop a more rapid and simpler uric acid biosensor.
These drugs include uricases
and selective uric acid reabsorption inhibitors.
To evaluate the mechanism whereby hyperuricemia impairs kidney function, we orally administered oxonic acid (OA), the uricase
inhibitor, to male Sprague-Dawley rats .
catalase, tyrosinase, peroxidase, and uricase
, functioning as a cofactor
Despite these promising data, we noticed that the plasma uric acid (UA) levels in most studies were normal or even low because of the degradation of uricase
, an enzyme that converts uric acid to allantoin, which is much more soluble than uric acid .
Arica, "Surface modification of polyacrylonitrile film by anchoring conductive polyaniline and determination of uricase
adsorption capacity and activity," Applied Surface Science, vol.
Hughes, "Effect of high dietary concentrations of brewer's dried yeast on growth performance and liver uricase
in rainbow trout (Oncorhynchus mykiss)," Animal Feed Science and Technology, vol.
Serum uric acid was measured using the uricase
In this procedure uric acid is oxidized with the uricase
, and in the presence of the generated hydrogen peroxide, a phenolic compound and 4-aminoantipyrine forms a red-colored quinoneimine and the absorbance of the quinoneimine chromagen, measured by spectrophotometry, is directly associated with the amount of uric acid in the sample (Thomas 1998).
Uric acid was originally measured in serum at visit 2 (1990-92) at the University of Minnesota using the Coulter DACOS system using an uricase
measurement procedure (interassay CV = 2.7%) (12).
It was revealed that uricase
inhibi-tor produce hyperuricemia, that initiated hypertension and reduced nitric oxide generation in the macula den-sa.