uric acid


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Related to uric acid: gout, Uric acid kidney stones

uric

 [u´rik]
uric acid the end product of purine metabolism or oxidation in the body. It is present in blood in a concentration of about 5 mg/100 ml and is excreted in the urine in amounts of a little less than 1 g per day. In gout there is an excess of uric acid in the blood, and its salts, the urates, form insoluble stones in the urinary tract, or may crystallize and form deposits (see tophus) in the joints and tissues. The presence of high concentrations of uric acid in the urine is significant in the diagnosis of gout, but is of little significance in urinary disorders.

u·ric ac·id

(yūr'ik as'id),
2,6,8-Trioxypurine; white crystals, poorly soluble, contained in solution in the urine of mammals and in solid form in the urine of birds and reptiles; sometimes solidified in small masses as stones or crystals or in larger concretions as calculi; with sodium and other bases it forms urates; elevated levels associated with gout.

uric acid

n.
A semisolid compound, C5H4N4O3, that is a nitrogenous end product of protein and purine metabolism and is the chief nitrogenous component of the urine in birds, terrestrial reptiles, and insects.

uric acid

A small purine metabolite excreted primarily by the kidneys, less by the GI tract; ↑ UA occurs in gout, which primarly affects acral joints, associated with deposition of UA crystals in various tissues; ↑ UA occurs in rapid cell turnover–eg, cancer–leukemia, metastases, myeloma, as well as in alcoholism, dehydration due to diuretics, DM, hyperlipoproteinemia, lead poisoning, renal failure, rarely, idiopathic Ref range Serum, ♂, 3.6-8.3 mg/dL; ♀, 2.2-6.8 mg/dL. See Gout. Cf Synovial fluid analysis.
Enlarge picture
CLUMP OF URIC ACID CRYSTALS (×400)

uric acid

C5H4N4O3, a crystalline acid occurring as an end product of purine metabolism. It is formed from purine bases derived from nucleic acids (DNA and RNA). It is a common constituent of urinary stones and gouty tophi. See: illustration
CAS # 69-93-2

Output

Uric acid must be excreted because it cannot be metabolized. Uric acid output should be between 0.8 and 1g/day if the patient is on an ordinary diet.

Increased elimination is observed after ingestion of proteins and nitrogenous foods, after exercise, after administration of cytotoxic agents, and in gout and leukemia. Decreased elimination is observed in kidney failure, lead poisoning, and in those who eat a protein-free diet.

See also: acid

uric acid

The main end product of PURINE metabolism. Uric acid is derived from ADENINE and GUANINE, two of the purines in DNA and RNA (nucleic acids). An excess of uric acid salts in the body can cause GOUT and kidney stones.

uric acid

see URATE.

Uric acid

A compound resulting from the body's breakdown of purine. It is normally present in human urine only in small amounts.
Mentioned in: Uric Acid Tests

u·ric ac·id

(yūr'ik as'id)
White crystals, poorly soluble, contained in solution in the urine of mammals.
References in periodicals archive ?
Hyperuricemia is a metabolic consequence originating with different etiologies concerned with either increased production or decreased excretion of uric acid or as a combination of both.
The charcoal absorbs uric acid, which will help to reduce the effects of gout on the body.
In the present study around 90% patients had calcium oxalate (60%), uric acid (18.18%) or calcium phosphate (10.90%) stones, while other forms of stones were scarce.
Katherine et al11 showed uric acid levels >3.6 mg/dl are linked with 3-fold higher possibility of developing GDM.
Drugs known as xanthine oxidase inhibitors (XOIs) block the activity of an enzyme involved in purine metabolism, thus reducing uric acid levels.
"If gout runs in the family, men in particular should limit their intake of alcohol, fats, and foods such as meat, sardines, bacon, mussels, and yeast that are more likely to increase the uric acid level in the body.
Uric acid + H20 Uricase Allantoin + H2O H2O2 + Phenolic chromogens Peroxidase Red coloured compound.
Effect of eprosartan and losartan on uric acid metabolism in patients with essential hypertension.
"Dietary strategies include limiting alcohol of all types, especially beer, limiting red meat and shellfish, and limiting high-fructose corn syrup, which is typically found in soft drinks." Your body produces uric acid when it breaks down purines, substances in these foods--the more purines, the more uric acid.
It is also unknown that uric acid independently can provide useful information during HF which needs further research.
'Various latest researches have indicated that high levels of uric acid are also an indicator of metabolic syndrome, which causes cardiovascular disease and stroke.
Solomon, M.D., from Brigham and Women's Hospital in Boston, and colleagues evaluated the association between canakinumab, a monoclonal antibody targeting interleukin-1β; serum uric acid levels; and the incidence of gout attacks.