the end product of purine
metabolism or oxidation in the body. It is present in blood in a concentration of about 5 mg/100 ml and is excreted in the urine in amounts of a little less than 1 g per day. In gout
there is an excess of uric acid in the blood, and its salts, the urates
, form insoluble stones in the urinary tract, or may crystallize and form deposits (see tophus
) in the joints and tissues. The presence of high concentrations of uric acid in the urine is significant in the diagnosis of gout
, but is of little significance in urinary disorders.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
u·ric ac·id (yūr'ik as'id),
2,6,8-Trioxypurine; white crystals, poorly soluble, contained in solution in the urine of mammals and in solid form in the urine of birds and reptiles; sometimes solidified in small masses as stones or crystals or in larger concretions as calculi; with sodium and other bases it forms urates; elevated levels associated with gout.
Farlex Partner Medical Dictionary © Farlex 2012
A semisolid compound, C5H4N4O3, that is a nitrogenous end product of protein and purine metabolism and is the chief nitrogenous component of the urine in birds, terrestrial reptiles, and insects.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
uric acid A small purine metabolite excreted primarily by the kidneys, less by the GI tract; ↑ UA occurs in gout, which primarly affects acral joints, associated with deposition of UA crystals in various tissues; ↑ UA occurs in rapid cell turnover–eg, cancer–leukemia, metastases, myeloma, as well as in alcoholism, dehydration due to diuretics, DM, hyperlipoproteinemia, lead poisoning, renal failure, rarely, idiopathic Ref range Serum, ♂, 3.6-8.3 mg/dL; ♀, 2.2-6.8 mg/dL. See Gout. Cf Synovial fluid analysis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
CLUMP OF URIC ACID CRYSTALS (×400)
, a crystalline acid occurring as an end product of purine metabolism. It is formed from purine bases derived from nucleic acids (DNA and RNA). It is a common constituent of urinary stones and gouty tophi. See: illustration
Uric acid must be excreted because it cannot be metabolized. Uric acid output should be between 0.8 and 1g/day if the patient is on an ordinary diet.
Increased elimination is observed after ingestion of proteins and nitrogenous foods, after exercise, after administration of cytotoxic agents, and in gout and leukemia. Decreased elimination is observed in kidney failure, lead poisoning, and in those who eat a protein-free diet.
Medical Dictionary, © 2009 Farlex and Partners
uric acid The main end product of PURINE metabolism. Uric acid is derived from ADENINE and GUANINE, two of the purines in DNA and RNA (nucleic acids). An excess of uric acid salts in the body can cause GOUT and kidney stones.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
uric acid see URATE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
A compound resulting from the body's breakdown of purine. It is normally present in human urine only in small amounts.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
u·ric ac·id (yūr'ik as'id)
White crystals, poorly soluble, contained in solution in the urine of mammals.
Medical Dictionary for the Dental Professions © Farlex 2012