uremia


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uremia

 [u-re´me-ah]
1. an excess in the blood of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism; more correctly referred to as azotemia.
2. in current usage, the entire complex of signs and symptoms of chronic renal failure. As the glomerular filtration rate falls in either acute tubular necrosis or chronic renal failure, serum urea (usually expressed as blood urea nitrogen content or BUN) and creatinine rise to very high levels. However, BUN and creatinine measurements are only roughly correlated with uremic symptoms. Other nitrogenous compounds present in small amounts may produce most of the toxic effects. Some uremic symptoms are due to losses of kidney function that do not involve uremia (azotemia). adj., adj ure´mic.
Patient Care. A major activity of care is assessment of health status and learning needs on an ongoing basis throughout the course of the illness. The systemic effects of uremia involve virtually every system of the body and present problems related to dysfunction of each system. Maintaining adequate nutrition is a very real challenge for the patient with this condition. The cooperative efforts of nutritionists and other health care professionals are needed to meet the goals of minimizing uremic toxicity, maintaining acceptable electrolyte levels, controlling hypertension, providing sufficient calories, and maintaining adequate nutritional status. Because of buildup of nitrogenous wastes from protein metabolism, dietary intake of protein may be severely limited. If any protein foods are allowed they should be of high quality; for example, eggs, milk, and cheese provide all of the essential amino acids in relatively small quantities.



Potassium restriction may also be indicated because of inability of the kidney to excrete it. This complicates the problem, however, because foods rich in potassium also are high-quality protein foods. These same foods also contain phosphorus, which may be restricted. A sodium-free diet usually is prescribed, but this can pose problems in regard to food selection and patient compliance.

Patients in the terminal stage of uremia will require special mouth care; measures to prevent pressure ulcers; protection from injury due to altered levels of consciousness; monitoring and protection from deleterious effects of excessive bleeding related to lack of renal hormone erythropoietin and bone marrow depression; and interventions appropriate to psychological and emotional support for the patient and family members during a terminal illness.
Systemic effects of uremia.

u·re·mi·a

(yū-rē'mē-ă),
1. An excess of urea and other nitrogenous waste in the blood.
2. The complex of symptoms due to severe persisting renal failure that can be relieved by dialysis.
[G. ouron, urine, + haima, blood]

uremia

also

uraemia

(yo͝o-rē′mē-ə)
n.
A toxic condition resulting from kidney disease in which there is retention in the bloodstream of waste products normally excreted in the urine. Also called azotemia.

u·re′mic adj.

uremia

Prerenal azotemia, renal underperfusion Nephrology A constellation of Sx caused by the retention of urea and other products of protein catabolism due to inadequate kidney function in advanced renal failure Clinical N&V, pruritus, uremic frost, mental clouding, peripheral neuropathies, osteodystrophy, HTN, CHF, pericarditis, pulmonary edema Lab Acidosis, anemia, azotemia, ↓ Ca2+, ↑ PO4, coagulopathy Pathogenesis 1º glomerular and/or tubular disease Management General support–restriction of protein, Na+, K+, and water; dialysis–hemodialysis, peritoneal dialysis; kidney transplant

Uremia

The presence of excessive amounts of urea and other waste products in the blood.
Mentioned in: Alport Syndrome

u·re·mi·a

(yūr-ē'mē-ă)
1. Excess of urea and other nitrogenous waste in blood.
2. Complex of symptoms due to severe persisting renal failure that can be relieved by dialysis.
Synonym(s): uraemia.
[G. ouron, urine, + haima, blood]
References in periodicals archive ?
Chronic nephritis in children lasting more than one or two years had a minimal prognosis for recovery, resulting in progressive manifestations of uremia, and ultimately, death.
The phenotype of uremia and its complex dysmetabolism presents an imbalanced relationship with DNA methylation; there's a combination of environmental and heritable factors.
Kugel et al., "Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia," Kidney International, vol.
Moderate uremia has been shown to modulate the phenotype of aortic smooth muscle cells (33).
Hence, it seems that the main factors of SSNHL are diuretics loop administration due to the oliguria, simultaneous kidney failure, and uremia.
In contrast, plasma glucose levels in diabetic patients with uremia (CRF) and diabetic patients with uremia who underwent RT both exceeded the normal range, and the CRF group showed a statistically higher abnormal concentration.
[16] reported that uremia impairs endothelial function and inhibits differentiation of endothelial progenitor cells.
However, in the uremia, the location and expression of AQP5 and UTs in skin have not been studied.
A perda da funcao renal ocorre devido aos disturbios em niveis tubulares, glomerulares e endocrinos, prejudicando a excrecao dos produtos finais do metabolismo, sendo alguns deles: ureia, acido urico, a creatinina, os fosfatos, os sulfatos e o excesso de acidos, resultando num acumulo excessivo de residuos metabolicos no organismo, gerando um quadro de uremia. As toxinas uremicas podem estar associadas ao prejuizo de varias funcoes cognitivas, sendo elas: delirio, depressao, comprometimento cognitivo e demencia que acometem varios aspectos das funcoes cerebrais, como: atencao, linguagem, memoria, aprendizagem, raciocinio, tomada de decisoes e resolucao de problemas.
30 May 2016 - 14:57 "NO" to the Violence is the Message of the 10th Parliament Election Rouhani Elaborated the Public Message of the Recent Election in a Rally in Urmia Province of Iran At the beginning of his speech He addressed people of Azerbaijan and reminding his word to the honorable people of this city before taking the office as the president about recovery of Uremia lake which has long been dried up for about a decade, ensured the public that recovery of this lake is one of his main concerns.
Novel assays with immortalized cardiac Gli1+ cells will allow high throughput screens to identify uremia associated factors of cell activation and inhibitory compounds to facilitate the development of novel therapeutics.