urate

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urate

 [u´rāt]
a salt of uric acid.

u·rate

(yū'rāt),
A salt of uric acid.

urate

(ūr´āt) any salt or anion of uric acid (q.v.).

urate

[yoo͡r′āt]
any salt of uric acid, such as sodium urate. Urates are found in urine, blood, and tophi or calcareous deposits in tissues. They also may be deposited as crystals in joints. See also gout, uric acid.

urate

(yūr'āt)
A salt of uric acid.

urate

A salt of uric acid.
Urateclick for a larger image
Fig. 311 Urate . Molecular structure.

urate (uric acid)

an end product of PURINE degradation in humans, which is excreted in the urine. Purine degradation proceeds further in other mammals so that urate is oxidized and ALLANTOIN, for example, is excreted. In land animals such as reptiles and birds, urate is excreted as the final product of nitrogen metabolism, instead of UREA, in order to conserve water. Purines are synthesized using their excess amino nitrogen and then degraded to urate. By eliminating nitrogen in this way there is a minimum of water loss and the urate is excreted either as a thick paste or as dry pellets. A high amount of urate in serum can cause gout, a disease that affects the joints and kidneys. Formula: C5H4N4O3.

urate

a salt of uric acid. Accumulates in tissues in large quantities in chickens fed excessive amounts of protein. See also visceral gout.

urate calculi
see urate uroliths.
References in periodicals archive ?
Asymptomatic hyperuricaemia is the 1st stage of gout in which the serum urate levels are raised.
10) In this study of 5,707 participants in the 2007-2008 NHANES, 74% had HTN, 71% had CKD stage 2 or higher, 53% were obese, 26% had diabetes, 24% had nephrolithiasis, 14% had myocardial infarction, 11% had heart failure, and 10% had suffered a stroke; the prevalence of these comorbidities were also noted to increase with the degree of hyperuricemia, supporting the notion that serum urate is related to the presence of several gout comorbidities, either as a marker of disease or perhaps by itself exacerbating other diseases.
Results showed that the prevalence of gout, hyperuricemia, and high serum urate levels all significantly increased during the past 2 decades.
Now we address the remaining stones that can affect our best friends: urate, cystine, calcium phosphate, silica, xanthine, and mixed or compound uroliths.
Uric acid is the main end product of nitrogen catabolism in birds and is relatively unbound to proteins in the plasma, forming urate salts with sodium and potassium at avian plasma pH.
The presence of monosodium urate monohydrate crystals in synovial fluid remains the gold standard for gout diagnosis, with a sensitivity of 84% and a specificity of 100%, according to new gout diagnostic guidelines issued by the European League Against Rheumatism.
5) There is no apparent reason, however, that refrigeration would specifically affect urate determination, as long as precipitated urates are returned to solution prior to analysis.
Urate lowering therapy to promote crystal dissolution and prevent crystal formation is achieved by maintaining the serum uric acid below the saturation point for monosodium urate (360 omol/l or 6 mg/dl).
6) Each participant consumed 80 grams of casein, lactalbumin, or soy protein, followed by measurement of serum and urinary urate levels for the next 180 minutes.
Cytologic examination of the white to yellow chalky aspirate material showed monosodium urate crystals (arrow, Fig 3), which were birefringent under polarized light (arrow, Fig 4).
They enrolled five adolescents with documented essential hypertension, all with serum urates of 6.
It addresses a high unmet medical need in an environment where less than half the patients have been receiving appropriate lifestyle advice and / or urate lowering treatment(1).