urate oxidase


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to urate oxidase: uricase, allopurinol

u·rate ox·i·dase

[MIM*191540]
a copper-containing, oxygen-requiring oxidoreductase that oxidizes uric acid; used in the clinical diagnosis of increased uric acid levels.
Synonym(s): uricase

urate ox·i·dase

(yūr'āt ok'si-dās)
A copper-containing, oxygen-requiring oxidoreductase that oxidizes uric acid; used in the clinical diagnosis of increased uric acid levels.
Synonym(s): uricase.

oxidase

(ok'si-das?, -daz?) [ oxide + -ase]
A class of enzymes present in plant and animal cells that catalyzes an oxidation reaction; a respiratory enzyme.

cytochrome oxidase

An enzyme present in most cells that oxidizes reduced cytochrome to cytochrome.

urate oxidase

Uricase.
References in periodicals archive ?
Treatment consisted of hydration and allopurinol; none of the patients received urate oxidase. Among the patients that developed TLS, 26.3% had laboratory TLS, 42.1% had grade I or II TLS, and 31.6% had grade III or IV TLS.
In recent years, recombinant urate oxidase has been introduced, which is an enzyme that exists in many mammalians, but not humans This enzyme allows urinary excretion of uric acid by converting it to allantoin, which is 5-10-fold more soluble in water than uric acid; however, urate oxidase causes hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency and is expensive.
Reiter, "Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidase," Annals of Hematology, vol.
Ha, "Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer.," Cochrane Database of Systematic Reviews, vol.
Wiley et al., "Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients with leukemia or lymphoma," Journal of Clinical Oncology, vol.
Purification of urate oxidase; a sex dependent enzyme from rat liver, Arch.
Purification and characterization of extracellular Pseudomonas aeruginosa urate oxidase enzyme, Pol.