urate oxidase


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Related to urate oxidase: uricase, allopurinol

u·rate ox·i·dase

[MIM*191540]
a copper-containing, oxygen-requiring oxidoreductase that oxidizes uric acid; used in the clinical diagnosis of increased uric acid levels.
Synonym(s): uricase

urate ox·i·dase

(yūr'āt ok'si-dās)
A copper-containing, oxygen-requiring oxidoreductase that oxidizes uric acid; used in the clinical diagnosis of increased uric acid levels.
Synonym(s): uricase.

oxidase

(ok'si-das?, -daz?) [ oxide + -ase]
A class of enzymes present in plant and animal cells that catalyzes an oxidation reaction; a respiratory enzyme.

cytochrome oxidase

An enzyme present in most cells that oxidizes reduced cytochrome to cytochrome.

urate oxidase

Uricase.
References in periodicals archive ?
Substitution of allopurinol with urate oxidase has been reported to decrease the incidence and severity of TLS (22), (23).
Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidase.
An example is that the investigators did not design the study to compare rasburicase with allopurinol because they felt that urate oxidase was the standard of care for hyperuricemia, which is different from current practice standards for adults in the USA.
Puricase is a PEGylated recombinant porcine urate oxidase currently in Phase 3 development for patients with treatment-failure gout.
Puricase, a pegylated recombinant porcine urate oxidase, is being developed to control hyperuricemia and its clinical consequences in patients for whom conventional therapy is contraindicated or has been ineffective.
Duke developed the recombinant porcine urate oxidase and MVP developed the PEGylation technology.
Integrated Communications Corporation (ICC), one of the nation's leading healthcare advertising agencies, announced today that it has been selected by Sanofi-Synthelabo as global agency of record for Rasburicase, its recombinant urate oxidase product.