urate


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Related to urate: Urate crystals, urate nephropathy

urate

 [u´rāt]
a salt of uric acid.

u·rate

(yū'rāt),
A salt of uric acid.

urate

(ūr´āt) any salt or anion of uric acid (q.v.).

urate

[yoo͡r′āt]
any salt of uric acid, such as sodium urate. Urates are found in urine, blood, and tophi or calcareous deposits in tissues. They also may be deposited as crystals in joints. See also gout, uric acid.

urate

(yūr'āt)
A salt of uric acid.

urate

A salt of uric acid.
Urateclick for a larger image
Fig. 311 Urate . Molecular structure.

urate (uric acid)

an end product of PURINE degradation in humans, which is excreted in the urine. Purine degradation proceeds further in other mammals so that urate is oxidized and ALLANTOIN, for example, is excreted. In land animals such as reptiles and birds, urate is excreted as the final product of nitrogen metabolism, instead of UREA, in order to conserve water. Purines are synthesized using their excess amino nitrogen and then degraded to urate. By eliminating nitrogen in this way there is a minimum of water loss and the urate is excreted either as a thick paste or as dry pellets. A high amount of urate in serum can cause gout, a disease that affects the joints and kidneys. Formula: C5H4N4O3.

urate

a salt of uric acid. Accumulates in tissues in large quantities in chickens fed excessive amounts of protein. See also visceral gout.

urate calculi
see urate uroliths.
References in periodicals archive ?
A treat-to-target strategy should be started with the goal of lowering the urate level to 0.
5-8) The increased level of cartilage degradation products in the joint fluid further lowers urate solubility and promotes nucleation and growth of MSU crystals.
Your GP will prescribe a course of anti-inflammatory drugs or, sometimes, colchicine - which works by reducing the ability of the urate crystals to inflame the joint lining (synovium).
The distribution of urate deposition within the extremities in gout: a review of 148 dualenergy CT cases.
Aspirate of hand and retrocalcaneal region shows needle shaped urate crystals (Figure 4).
In addition, we measured the serum levels of calcium, phosphorus, creatinine, urate and parathormone.
As is known, salicylic acid is uricosuric at doses over 4-5 g/day, whereas lower doses can cause hyperuricemia via urate retention (20,21).
In recent years, recombinant urate oxidase has been introduced, which is an enzyme that exists in many mammalians, but not humans This enzyme allows urinary excretion of uric acid by converting it to allantoin, which is 5-10-fold more soluble in water than uric acid; however, urate oxidase causes hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency and is expensive.
Raising the amount of urate is one of the "more promising" strategies in development, said senior study author Michael Schwarzschild.
A clinical trial has been launched to see whether the amount of urate in blood and cerebrospinal fluid has any potential benefits for patients.
Individuals with Parkinson's disease who have higher levels of a metabolite called urate in their blood and in cerebrospinal fluid (CSF) have a slower rate of disease progression, according to a study funded by the National Institutes of Health.