urate


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

urate

 [u´rāt]
a salt of uric acid.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

u·rate

(yū'rāt),
A salt of uric acid.
Farlex Partner Medical Dictionary © Farlex 2012

urate

(yūr'āt)
A salt of uric acid.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

urate

A salt of uric acid.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
Urateclick for a larger image
Fig. 311 Urate . Molecular structure.

urate (uric acid)

an end product of PURINE degradation in humans, which is excreted in the urine. Purine degradation proceeds further in other mammals so that urate is oxidized and ALLANTOIN, for example, is excreted. In land animals such as reptiles and birds, urate is excreted as the final product of nitrogen metabolism, instead of UREA, in order to conserve water. Purines are synthesized using their excess amino nitrogen and then degraded to urate. By eliminating nitrogen in this way there is a minimum of water loss and the urate is excreted either as a thick paste or as dry pellets. A high amount of urate in serum can cause gout, a disease that affects the joints and kidneys. Formula: C5H4N4O3.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
However, the accumulation of oxypurinol in CKD patients also raises the possibility that, on a dose-by-dose basis, allopurinol may be more effective at urate lowering in patients with kidney insufficiency.
(2) In 2012, the American College of Rheumatologists (ACR) issued guidelines for the management of gout; however, no specific therapeutic measure was recommended for AH, even though it is a major precursor of gout and is frequently associated with subclinical deposition of urate in joints.
The researchers found that in the male, female, or full cohorts, seven foods were associated with elevated serum urate levels (beer, liquor, wine, potato, poultry, soft drinks, and meat) and eight were associated with reduced serum urate levels (eggs, peanuts, cold cereal, skim milk, cheese, brown bread, margarine, and non-citrus fruits).
The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study.
The provider-patient relationship should involve shared decision-making, patient education, reducing and maintaining a serum urate level below a defined target (i.e., below 6 mg/dl given that the limit of solubility of uric add is 6.8 mg/dl), and long-term adherence to urate-lowering therapy in order to maintain the target serum urate."
The basic pathophysiological feature of gout is the deposition of monosodium urate crystals in the synovial fluid of the joints following longstanding hyperuricemia.
The serum urate level is affected by age, sex, race, heredity, food habits, drugs, environment, and other factors.
Thus, given these assumptions, a genetic variant associated with plasma urate should be related to the outcome risk as predicted by its influence on plasma urate (14).
Uric acid is the main end product of nitrogen catabolism in birds and is relatively unbound to proteins in the plasma, forming urate salts with sodium and potassium at avian plasma pH.
Those in the study with the highest amounts of the antioxidant, urate, in their blood were 36% less likely to need treatment within two years for early Parkinson's symptoms than those with the lowest levels, research published last week online in the Archives of Neurology showed.
A clinical trial has been launched to see whether the amount of urate in blood and cerebrospinal fluid has any potential benefits for patients.