upregulation


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up·reg·u·la·tion

(ŭp'reg-yū-lā'shŭn),
Opposite of down-regulation.

up·reg·u·la·tion

(ŭp'reg'yū-lā'shŭn)
Opposite of downregulation.

up·reg·u·la·tion

(ŭp'reg'yū-lā'shŭn)
Opposite of downregulation.
References in periodicals archive ?
In summary, we have shown that the upregulation of SelS improves the viability of endothelial cells, enhances the levels of NO and eNOS, reduces the production of ET-1 and ROS, and inhibits the adhesion of TNF-[alpha]-induced THP-1 cells to endothelial cells.
We further found GBP1 was required for IFN-[gamma]-induced upregulation of matrix metalloproteinase 2 (MMP2) expression in PDLSCs.
Upregulation of FBXW7 Expression Inhibited RCC Cell Migration and Invasion In Vitro.
fumigatus; among them, upregulation of conidial stress-related genes and downregulation of genes related to germination are notable [20].
It has also been reported that reduced proliferative capacity, upregulation of inhibitory receptors, such as programmed death 1 (PD-1), and B cell dysfunction are present in cells derived from sarcoidosis patients experiencing disease progression [5-9].
All three pathways, PERK, IRE1, and ATF6, ultimately evoke an adaptive response through upregulation of the key ER chaperones, repression of protein translation, and stimulation of protein degradation by ER-associated degradation (ERAD) mechanism.
Upregulation of MMP2 expression and activity have been reported in VSMCs and animal calcification models, which mediate elastin degradation, producing soluble elastin peptides and causing release and activation of the latent TGF-[beta]1 complex from the extracellular matrix of vessel walls.
In uterus, [E.sub.2] treatment resulted in several hundredfold significant upregulation of the mRNA encoding C3 and CaBP9k, accompanied by a significant downregulation of Clu mRNA expression (Figure 3(b)).
In two Phase 2 clinical trials that enrolled more than 900 older adults, RTB101 was observed to improve immune function by upregulation of pan antiviral gene expression and to reduce the incidence of RTIs.
The trial showed that regular UA dosing during four weeks is safe, bioavailable and effective in improving mitochondrial health through upregulation of mitochondrial gene expression localised to the skeletal muscle and by improving systemic plasma acylcarnitines associated with cellular and mitochondrial function.
Moreover, HBeAg induced the expansion of MDSCs through the upregulation of a molecule called indoleamine-2, 3-dioxygenase (IDO), which plays a critical role in the suppression of T-cell proliferation.
Recently, we could demonstrate that inflammatory mediators and periodontopathogens are able to induce an initial GHS-R1a upregulation in periodontal fibroblasts.