STK-001 is designed to selectively upregulate
one allele of the SCN1A gene to restore the protein expression to near-normal levels.
STK-001 is designed to upregulate
NaV1.1 protein expression from the non-mutant (wild type) copy of the SCN1Agene to restore physiological NaV1.1 levels, thereby reducing both occurrence of seizures and significant non-seizure comorbidities.
DEL106 is an IL-2 mutein Fc fusion protein designed to upregulate
regulatory T cells (Tregs), which are critical to maintaining immune system balance.
Several studies have demonstrated that increased PPAR[gamma] can upregulate
CD36 expression and function, while PPAR[gamma] knockout can dramatically reduce CD36 expression and function in many different types of cells, including macrophages, hepatocytes, and kidney cells [24-27].
In the presence of PMA/I stimulation, the effects of IL27 do not seem to be greatly altered (Figure 8(d)), and miRNAs are generally similar, except that miR-let7f appears to augment TNF and TLR10 and miR-20b and miR-21 appear to upregulate
TNF and/or IL-17a (Figure 8(e)).
However, HMGB1 alone did not upregulate
the expression of MMP-3, MMP-13, or ADAMTS-5 (Figure 1, lane 10) although it did upregulate
the expression of pro-MMP13 moderately.
Prior to the consummation of the acquisition, Acetylon will spin out a new company, Regenacy Pharmaceuticals, LLC, which will focus on the development of novel drug candidates that selectively regenerate intracellular transport and upregulate
gene expression to modify the course of disease.
The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), another promising tumor suppressor protein, has been shown to upregulate
"We now hope to be able to restore the ability to upregulate
CHD5 in aggressive tumor cells and make them mature into harmless nerve cells."
On the other hand, in our study Juzen-taiho-to did not upregulate
the population of CD16-negative CD158a/b-positive cells; it upregulated only CD16-positive CD158a/b-positive cells.
Once infected, pDCs traffic HIV into the T-cell areas of lymphoid tissues, where they generate IFN-[alpha], upregulate
IL-12 receptors, and produce HIV.
"If you could upregulate
[increase] maspin production, it's potentially a new therapeutic direction," comments William Stetler-Stevenson at the National Cancer Institute in Bethesda, Md.