, hemoglobins with altered oxygen affinity, hemoglobin M, and other variants of clinical and biological interest.
Oxidative denaturation in congenital hemolytic anemias: the unstable hemoglobins
However, unstable hemoglobins co-expressed with [alpha]-thalassemia minor can produce HbH disease in the same patient populations.
An interesting sickle cell compound heterozygote involving the unstable hemoglobin Volga produces a diagnostic dilemma.
Hb Sallenches [a104(GI 1) Cys>Tyr, TGC>TAC (a,2)]: an unstable hemoglobin variant found in an Indian child.
Two unstable hemoglobins
are present in the blood and both have a higher affinity for oxygen than normal hemoglobin, resulting in poor oxygen delivery to tissues.
2) Hereditary hemoglobinopathies include abnormal hemoglobins: sickling disorders, unstable hemoglobins
, abnormal oxygen affinities, and methemoglobins (hemoglobins M), disorders of hemoglobin chain production ([alpha] and [beta] thalassemias), and methemoglobinemias due to nicotinamide adenine dinucleotide diaphorase deficienc y.
Unstable hemoglobins, hemoglobins with altered oxygen affinity, hemoglobin M and other variants of clinical and biological interest.
5]), Hb M anomalies, unstable hemoglobin variants, and easily oxidizable variants.
Impaired binding of AHSP to [alpha] chain variants: Hb Groene Hart illustrates a mechanism leading to unstable hemoglobins with [alpha] thalassemic like syndrome.
Hemoglobin Debrousse [[beta]96(FG3)Leu[right arrow]Pro]: a new unstable hemoglobin with twofold increased oxygen affinity.