For United Kingdom-based Mallinckrodt, the deal would bring a pair of currently marketed pharmaceutical products: Amitiza (lubiprostone), a medication for constipation, and Rescula (unoprostone
isopropyl ophthalmic solution 0.15%), a treatment for ocular hypertension and open-angle glaucoma.
 discontinued monotherapy PGA prior to starting a crossover trial of either unoprostone
Through the acquisition, Mallinckrodt adds a second commercial asset from Sucampo which is Rescula (unoprostone
isopropyl ophthalmic solution) 0.15%.
Changes in ocular surface caused by antiglaucomatous eyedrops: prospective, randomised study for the comparison of 0.5% timolol and 0.12% unoprostone
. Br J Ophthalmol.
Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone
, considering 24-hour variation.
reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels," Molecular Vision, vol.
(Approved in 2000) [Fellman RL, Sullivan EK, Ratliff M, et al].
There are no human eye data for unoprostone
isopropyl (Rescula), a synthetic docosanoid.
The company also receives revenue from sales of Rescula (unoprostone
isopropyl) in Japan.
, used as the isopropyl ester for the treatment of glaucoma and ocular hypertension, is like latanoprost, a synthetic analogue of dinoprost (prostaglandin F2a).
Prostaglandin analogs (latanoprost, travoprost, unoprostone
) increase drainage of the aqueous humor.
Kitazawa, "Ocular hypotensive mechanism of topical isopropyl unoprostone
, a novel prostaglandin metabolite-related drug, in rabbits," Journal of Ocular Pharmacology and Therapeutics, vol.