unoprostone


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unoprostone

 [u″no-pros´tōn]
an antiglaucoma agent that decreases elevated intraocular pressure by increasing the outflow of aqueous humor; used as unoprostone isopropyl in the treatment of open-angle glaucoma and ocular hypertension, applied topically to the conjunctiva.
References in periodicals archive ?
For United Kingdom-based Mallinckrodt, the deal would bring a pair of currently marketed pharmaceutical products: Amitiza (lubiprostone), a medication for constipation, and Rescula (unoprostone isopropyl ophthalmic solution 0.15%), a treatment for ocular hypertension and open-angle glaucoma.
[18] discontinued monotherapy PGA prior to starting a crossover trial of either unoprostone and latanoprost.
Through the acquisition, Mallinckrodt adds a second commercial asset from Sucampo which is Rescula (unoprostone isopropyl ophthalmic solution) 0.15%.
Changes in ocular surface caused by antiglaucomatous eyedrops: prospective, randomised study for the comparison of 0.5% timolol and 0.12% unoprostone. Br J Ophthalmol.
Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation.
Hara, "Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels," Molecular Vision, vol.
(1) Unoprostone (Approved in 2000) [Fellman RL, Sullivan EK, Ratliff M, et al].
There are no human eye data for unoprostone isopropyl (Rescula), a synthetic docosanoid.
The company also receives revenue from sales of Rescula (unoprostone isopropyl) in Japan.
Unoprostone, used as the isopropyl ester for the treatment of glaucoma and ocular hypertension, is like latanoprost, a synthetic analogue of dinoprost (prostaglandin F2a).
Prostaglandin analogs (latanoprost, travoprost, unoprostone) increase drainage of the aqueous humor.
Kitazawa, "Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits," Journal of Ocular Pharmacology and Therapeutics, vol.