In order to induce type 2 diabetic rats, the DKD model rats were first treated with
uninephrectomy to induce hyperfiltration and hyperperfusion and then developed by high-fat diet (67.5% standard fodder, 20% sucrose, 10% lard oil, and 2.5% cholesterol) for 4 weeks.
Four groups of rats were studied: (1)
uninephrectomy (U-NX) group (n = 3), rats were injected i.p.
Indeed, in analogy, experimental renal hypertrophy, induced by
uninephrectomy or with high protein diet, enhances renal medullary Na-K-ATPase content and predisposes to outer medullary hypoxic injury in isolated rat kidneys, perfused with red-cell-free oxygenated medium [26].
Bijol and colleagues report a very high incidence of renal abnormalities, with only 25% of the kidneys showing an entirely normal architecture.[sup.17] These abnormalities were associated with a more pronounced decrease in renal function after
uninephrectomy, compared to patients with normal parenchyma, as could be anticipated from studies in living kidney donors.[sup.18] Related to the procedure itself, renal artery clamping and renal cooling have been applied to reduce bleeding.
Adaptation of NA+/H+ exchange in renal microvillus membrane vesicles: Role of dietary protein and
uninephrectomy. J Clin Invest 1984: 74:1979-1987.
Status patients who underwent
uninephrectomy in adulthood more than 20 years ago.
The role of the kidney in Hcy metabolism is supported by the finding that Hcy concentrations increased in living kidney donors after
uninephrectomy and remained high 6 months thereafter, despite folate and vitamin [B.sub.12] remaining unchanged (31).
Glomerular damage after
uninephrectomy in young rats.
Epstein, "
Uninephrectomy of diabetic OVE26 mice greatly accelerates albuminuria, fibrosis, inflammatory cell infiltration and changes in gene expression," Nephron.
Glomerular damage after
uninephrectomy in young rats, II: mechanical stress on podocytes as a pathway to sclerosis.
Glomerular damage after
uninephrectomy in young rats, I: hypertrophy and distortion of capillary architecture.