Non-reoperative primary hyperparathyroid patients were further subdivided into patients with uniglandular or multiglandular disease.
5 displays results from four patients with uniglandular disease who were considered cured based on post-surgical calcium concentrations but in whom a 50% decline in PTH concentrations was not achieved.
22) validated assay accuracy in 72 patients undergoing bilateral exploration for primary hyperparathyroidism, using gross morphologic criteria to identify uniglandular or multiglandular disease.
Eight of these patients--4 with primary hyperplasia and 4 with double adenomas--were thought preoperatively to have uniglandular disease (Figure 4).
The qPTH assay has been successfully utilized in patients with uniglandular disease by several authors (7-10).
In patients with renal failure, our data showed that not only was the qPTH successful in predicting postoperative normocalcemia, but assay levels dropped appropriately 5 minutes after subtotal resection, which is consistent with results for most patients with uniglandular disease.