undifferentiated connective tissue disease


Also found in: Acronyms.

undifferentiated connective tissue disease

An early stage of a connective tissue disease, in which the predominant organ of involvement or clinical form is not yet manifest. Cf Overlap syndrome, Palindromic rheumatism.

undifferentiated connective tissue disease

,

UCTD

A connective tissue disease that does not fully meet the criteria for any of the well-defined rheumatological conditions such as rheumatoid arthritis, Sjögren's syndrome, or systemic lupus erythematosus. Signs and symptoms of connective tissue disease must be present for several years. These may include polyarticular arthritis, Raynaud's phenomenon, pleuritis, or pericarditis, among others. The patient with UCTD will also have a positive antinuclear antibody test as well as other autoantibodies. Diagnostic difficulties in UCTD may be found in people who have evidence of mixed connective tissue disease or overlap syndrome.
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References in periodicals archive ?
Petroleum distillate solvents as risk factors for undifferentiated connective tissue disease (UCTD).
Undifferentiated connective tissue disease: natural history and evolution into definite CTD assessed in 84 patients initially diagnosed as early UCTD.
Undifferentiated connective tissue disease: analysis of 83 patients with a minimum followup of 5 years.
All tissue specimens were from a cohort containing diverse ILDs, including IPF, undifferentiated connective tissue disease, idiopathic NSIP, cryptogenic organizing pneumonia, and unclassifiable IIP.
Before publication of the IPAF criteria, those 176 patients carried the following diagnoses: IPF (n = 109; 61.9%), undifferentiated connective tissue disease (n = 47; 26.7%), unclassifiable IIP (n = 12; 6.8%), cryptogenic organizing pneumonia (n = 5; 2.8%), and idiopathic NSIP (n = 3; 1.7%) (Figure 1).
Two of these patients (2 of 3; 67%) had scleroderma and one (1 of 3; 33%) had undifferentiated connective tissue disease. In both groups, patients without multilobar NSIP-P demonstrated widened alveolar walls only in the areas adjacent to fibrosis, which was not seen in areas distant from fibrosis (Figure 3, A through F).
This resulted in the concept of undifferentiated connective tissue disease, a term used for patients presenting with Raynaud phenomenon alone, characteristic rashes resembling those seen in certain RDs, but without other symptoms, inflammatory polyarthritis, or serologic markers with clinical abnormalities that do not fulfill criteria for a specific RD.

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