Substances such as dinitrophenol that allow oxidation in mitochondria to proceed without the usual concomitant phosphorylation to produce ATP; these poisons thus "uncouple" oxidation and phosphorylation.
Synonym(s): uncoupling factors
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The UCP are mitochondrial carrier proteins located in the inner membrane, and considered uncouplers, because these proteins are capable of dissociating ATP synthesis from the respiratory chain by dissipating the proton gradient.
Either of these uncouplers decreased the ATP content per cell to 970% of that of untreated cells.
Nitrophenols are known protonophores and have been used in structural alert models to define uncouplers (Naven et al.
They can block electron acceptors, act as energy uncouplers and reduce the activity of photosynthetic pigments and enzymes (Einhellig and Rasmussen, 1979).
This has been demonstrated by the protonophore electron uncouplers 2,4-dinitrophenol (117) and FCCP (118), as well as with isoflurane (102).
This is consistent with previous findings that showed that kava extracts act as inhibitors and uncouplers of the respiratory chain and inhibitors of [beta]-oxidation in isolated liver mitochondria (Lude et al.
There is work which suggests that using this technique can eliminate fat-soluble residues of PCBs, pesticides, and similar possible metabolic uncouplers or immunologic suppressants through the skin, especially when combined with proper transport cofactors (the antioxidants and B-complex such as that found in comprehensive formulas).
Pyrrole insecticide: a newclass of agriculturally important insecticides functioning as uncouplers of oxidative phosphorylation.
Recent studieshave shown that antimalarial drugs including CHQ decrease cytochrome aa3 and b content and adversely affect mitochondrial energy transduction in vivo by acting as uncouplers of oxidative phosphorylation (102).
Uncouplers longed to simplify their lives by uncoupling the smaller and more prized systems to which they belong from the larger ones in which these are entangled.
To determine whether gap-junction uncouplers can affect the percentage of oocyte maturation achieved, intact ovaries were immersed for 1-2 h in 12 [degrees]-16 [degrees] C SW solutions of 1 mM heptanol or 25 [[micro]molar] [Alpha]-glycyrrhetinic acid (AGA) before being macerated.