Gilbert syndrome

(redirected from unconjugated hyperbilirubinaemia)

fa·mil·i·al non·he·mo·lyt·ic jaun·dice

mild jaundice due to increased amounts of unconjugated bilirubin in the plasma without evidence of liver damage, biliary obstruction, or hemolysis; thought to be due to an inborn error of metabolism in which the excretion of bilirubin by the liver is defective, ascribed to decreased conjugation of bilirubin as a glucuronide or impaired uptake of hepatic bilirubin; autosomal dominant inheritance.
Farlex Partner Medical Dictionary © Farlex 2012

Gilbert syndrome

A benign hereditary condition (OMIM:143500) in which reduced bilirubin transferase activity results in intermittent hyperbilirubinaemia.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Gilbert syndrome

Constitutional liver dysfunction, low-grade chronic hyperbilirubinemia An inherited defect in bilirubin metabolism Clinical Jaundice, weakness, fatigue, nausea, abdominal pain. Cf Criggler-Najjar disease.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


Nicholas A., French physician, 1858-1927.
Gilbert disease - Synonym(s): familial nonhemolytic jaundice
Gilbert syndrome - Synonym(s): familial nonhemolytic jaundice
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates.
The patient also had a raised CRP of 184 mg/L and deranged LFTs with an unconjugated hyperbilirubinaemia and elevated ductal enzymes, i.e.
Tsai, "Urinary tract infections in infants: Comparison between those with conjugated vs unconjugated hyperbilirubinaemia," Annals of Tropical Paediatrics, vol.
It can lead to severe disability and death from kernicterus due to unconjugated hyperbilirubinaemia. The underlying problem is impaired bilirubin conjugation and elimination due to a mutation in uridine 5'-diphosphate glucuronyl transferase.
[26-28] RIF may occasionally cause dose-dependent interference with bilirubin uptake, resulting in subclinical, unconjugated hyperbilirubinaemia or jaundice without hepatocellular damage.
We also reviewed the outcomes of pregnant women with Crigler-Najjar syndrome, caused by bilirubin-uridine-glucuronosyltransferase gene mutations, a disease complicated by unconjugated hyperbilirubinaemia. The metabolism of bilirubin in Crigler-Najjar syndrome is similar to that in a fetus, i.e.
However, she developed unconjugated hyperbilirubinaemia on second day of life and the bilirubin level reached peak of 33.6mg/dl (indirect=32.3; direct=1.4) on sixth day of life.
* Isolated unconjugated hyperbilirubinaemia (drug-induced Gilbert's syndrome) is generally benign and associated with some PIs (indinavir and atazanavir).